{"id":"W2120667564","doi":"10.1053/j.gastro.2003.10.051","title":"Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B 1 1The Adefovir Dipivoxil International 461 Study Group includes the following: N. Afdhal (Beth Israel Deaconess Medical Center, Boston, MA); P. Angus (Austin and Repatriation Medical Centre, Melbourne, Australia); Y. Benhamou (Hopital La Pitie Salpetriere, Paris, France); M. Bourliere (Hopital Saint Joseph, Marseille, France); P. Buggisch (Universitaetsklinikum Eppendorf, Department of Medicine, Hamburg, Germany); P. Couzigou (Hopital Haut Leveque, Pessac, France); P. Ducrotte and G. Riachi (Hopital Charles Nicolle, Rouen, France); E. Jenny Heathcote (Toronto Western Hospital, Toronto, Ontario, Canada); H. W. Hann (Jefferson Medical College, Philadelphia, PA); I. Jacobson (New York Presbyterian Hospital, New York, NY); K. Kowdley (University of Washington Hepatology Center, Seattle, WA); P. Marcellin (Hopital Beaujon, Clichy, France); P. Martin (Cedars-Sinai Medical Center, Los Angeles, CA); J. M. Metreau (Centre Hospitalier Universitaire Henri Mondor, Creteil, France); M. G. Peters (University of California, San Francisco, San Francisco, CA); R. Rubin (Piedmont Hospital, Atlanta, GA); S. Sacks (Viridae Clinical Sciences, Inc., Vancouver, Canada); H. Thomas (St. Mary’s Hospital, London, England); C. Trepo (Hopital Hôtel Dieu, Lyon, France); D. Vetter (Hopital Civil, Strasbourg, France); C. L. Brosgart, R. Ebrahimi, J. Fry, C. Gibbs, K. Kleber, J. Rooney, M. Sullivan, P. Vig, C. Westland, M. Wulfsohn, and S. Xiong (Gilead Sciences, Inc., Foster City, CA); D. F. Gray (GlaxoSmithKline, Greenford, Middlesex, England); R. Schilling and V. Ferry (Parexel International, Waltham, MA); and D. Hunt (Covance Laboratories, Princeton, NJ).","year":2003,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":554,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Adefovir; Lamivudine; Virology; Hepatitis B virus; Hepatitis B; Chronic hepatitis; HBeAg; Gastroenterology; Medicine; Internal medicine; Virus; HBsAg","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006284104,0.0004806496,0.001798838,0.0003759536,0.0003874226,0.0006142096,0.0002484493,0.0005623102,0.002055259],"category_scores_gemma":[0.001296992,0.0002506882,0.0008078803,0.0006274233,0.0001990419,0.0005888136,0.0002248336,0.001024395,0.0002894684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005602121,"about_ca_system_score_gemma":0.0005583953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001756183,"about_ca_topic_score_gemma":0.005727979,"domain_scores_codex":[0.9994963,0.0002162291,0.00004613395,0.00008440539,0.00005387056,0.0001030752],"domain_scores_gemma":[0.9996228,0.00012103,0.00005653586,0.00001267346,0.00001612326,0.0001708382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3844504,0.003651705,0.2859754,0.002093388,0.002779882,0.001791894,0.0004045181,0.001042475,0.008906561,0.0003046055,0.007311816,0.3012874],"study_design_scores_gemma":[0.1139881,0.1263182,0.7205007,0.001136149,0.005210245,0.003089539,0.000877741,0.003761761,0.002501459,0.0008047798,0.02169942,0.000111963],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.945037,0.04759281,0.0002258693,0.001200525,0.0003767497,0.0002264426,0.0008329774,0.00002227291,0.004485306],"genre_scores_gemma":[0.992583,0.005141228,0.0002964987,0.0003622477,0.0002456263,0.00009186459,0.000484154,0.000004928666,0.0007902606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002055259,"threshold_uncertainty_score":0.006875515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008087156946633995,"score_gpt":0.221100717287068,"score_spread":0.213013560340434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}