{"id":"W2120667564","doi":"10.1053/j.gastro.2003.10.051","title":"Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B 1 1The Adefovir Dipivoxil International 461 Study Group includes the following: N. Afdhal (Beth Israel Deaconess Medical Center, Boston, MA); P. Angus (Austin and Repatriation Medical Centre, Melbourne, Australia); Y. Benhamou (Hopital La Pitie Salpetriere, Paris, France); M. Bourliere (Hopital Saint Joseph, Marseille, France); P. Buggisch (Universitaetsklinikum Eppendorf, Department of Medicine, Hamburg, Germany); P. Couzigou (Hopital Haut Leveque, Pessac, France); P. Ducrotte and G. Riachi (Hopital Charles Nicolle, Rouen, France); E. Jenny Heathcote (Toronto Western Hospital, Toronto, Ontario, Canada); H. W. Hann (Jefferson Medical College, Philadelphia, PA); I. Jacobson (New York Presbyterian Hospital, New York, NY); K. Kowdley (University of Washington Hepatology Center, Seattle, WA); P. Marcellin (Hopital Beaujon, Clichy, France); P. Martin (Cedars-Sinai Medical Center, Los Angeles, CA); J. M. Metreau (Centre Hospitalier Universitaire Henri Mondor, Creteil, France); M. G. Peters (University of California, San Francisco, San Francisco, CA); R. Rubin (Piedmont Hospital, Atlanta, GA); S. Sacks (Viridae Clinical Sciences, Inc., Vancouver, Canada); H. Thomas (St. Mary’s Hospital, London, England); C. Trepo (Hopital Hôtel Dieu, Lyon, France); D. Vetter (Hopital Civil, Strasbourg, France); C. L. Brosgart, R. Ebrahimi, J. Fry, C. Gibbs, K. Kleber, J. Rooney, M. Sullivan, P. Vig, C. Westland, M. Wulfsohn, and S. Xiong (Gilead Sciences, Inc., Foster City, CA); D. F. Gray (GlaxoSmithKline, Greenford, Middlesex, England); R. Schilling and V. Ferry (Parexel International, Waltham, MA); and D. Hunt (Covance Laboratories, Princeton, NJ).","year":2003,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":554,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Adefovir; Lamivudine; Virology; Hepatitis B virus; Hepatitis B; Chronic hepatitis; HBeAg; Gastroenterology; Medicine; Internal medicine; Virus; HBsAg","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.002501071,0.002282534,0.004257249,0.0006990367,0.001205088,0.0001960209,0.002056066,0.001426529,0.00115425],"category_scores_gemma":[0.0007048139,0.002051117,0.0003643809,0.001057473,0.004499943,0.001978263,0.00162217,0.002497941,0.000001676904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00197386,"about_ca_system_score_gemma":0.004185624,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.7304344,"about_ca_topic_score_gemma":0.9780214,"domain_scores_codex":[0.9839419,0.001503621,0.003284805,0.003482505,0.005218347,0.002568807],"domain_scores_gemma":[0.992199,0.0009053048,0.002599462,0.001277849,0.0008962482,0.002122134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003745075,0.003501605,0.9484109,0.0006098088,0.0016614,0.002855024,0.003225609,0.0000176746,0.000009292608,0.00006985981,0.03431765,0.001576103],"study_design_scores_gemma":[0.06277988,0.01057748,0.8706117,0.003331377,0.0005620591,0.0003983659,0.004332308,0.0007953639,0.000009695872,0.00003355274,0.04467792,0.001890258],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600236,0.02004536,0.0005362867,0.006191881,0.002932603,0.004448296,0.005617404,0.00009990689,0.0001046705],"genre_scores_gemma":[0.9810694,0.01415242,0.0009124862,0.0006369308,0.000523157,0.00005099116,0.001827083,0.0002032417,0.0006242361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.247587,"threshold_uncertainty_score":0.9998698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008087156946633995,"score_gpt":0.221100717287068,"score_spread":0.213013560340434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}