{"id":"W2120674430","doi":"10.1021/bi901432d","title":"Succinylphosphonate Esters Are Competitive Inhibitors of MenD That Show Active-Site Discrimination between Homologous α-Ketoglutarate-Decarboxylating Enzymes","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Active site; Enzyme; Decarboxylation; Biochemistry; Chemistry; Biosynthesis; Stereochemistry; Non-competitive inhibition; Dehydrogenase; Mycobacterium tuberculosis; Catalysis; Tuberculosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000218035,0.0003453903,0.0003656237,0.00005327273,0.0001480492,0.00003219078,0.0003587918,0.0004412799,0.00002871502],"category_scores_gemma":[0.0004284658,0.0002901089,0.0001791675,0.0001549474,0.0006465951,0.0000118196,0.0004680596,0.0004523589,0.000004434768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003923465,"about_ca_system_score_gemma":0.00008894374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004168498,"about_ca_topic_score_gemma":0.00003940261,"domain_scores_codex":[0.9981376,0.00004604017,0.0003278327,0.0006535787,0.000372577,0.0004623569],"domain_scores_gemma":[0.9986811,0.00008232104,0.0003215225,0.0004727437,0.0002645008,0.0001777667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001059587,0.00007473196,0.03538498,0.0001336006,0.0001378476,0.00000547909,0.0001063971,0.000001216599,0.9618458,0.00001823557,0.0004827861,0.001702993],"study_design_scores_gemma":[0.0004957438,0.0001095114,0.01802796,0.00006320533,0.00003838289,0.000008778951,0.0007361249,0.000009506682,0.9794222,0.0000317083,0.000713107,0.0003438353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970641,0.0005471339,0.00004276696,0.0004613937,0.0001537548,0.0002123256,0.0003879972,0.00002993582,0.001100556],"genre_scores_gemma":[0.9980565,0.00008178256,0.000491991,0.00003533755,0.000351051,0.00003742021,0.0005425291,0.00003848836,0.0003648935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01757636,"threshold_uncertainty_score":0.9999551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125347375493745,"score_gpt":0.2599805304366767,"score_spread":0.2474457928873022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}