{"id":"W2120692021","doi":"10.1128/iai.00446-08","title":"<i>Escherichia coli</i>O157:H7 Survives within Human Macrophages: Global Gene Expression Profile and Involvement of the Shiga Toxins","year":2008,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; Biotechnology Research Institute; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Shiga toxin; Microbiology; Escherichia coli; Virulence; Gene; Pathogen; Operon; Enterobacteriaceae; Downregulation and upregulation; Mutant; Human pathogen; Macrophage; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395409,0.000217066,0.000382803,0.000268916,0.000118688,0.0003266761,0.00006470409,0.0002771943,0.0007520814],"category_scores_gemma":[0.0000941065,0.00009174291,0.000223711,0.0002892234,0.000182238,0.0001719415,0.0001440357,0.0002004893,0.0002667021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001317844,"about_ca_system_score_gemma":0.0001289074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000432644,"about_ca_topic_score_gemma":0.000477939,"domain_scores_codex":[0.9998654,0.00002050212,0.00001120039,0.00003682138,0.00002552494,0.00004049186],"domain_scores_gemma":[0.999918,0.00001494563,0.00002093592,0.000006708071,0.00002274039,0.00001662168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001560932,0.00001352459,0.001441291,0.00003950028,0.000005328923,0.00005574269,0.00002972484,0.00002541,0.9974182,0.00001252006,0.00003690257,0.0007657964],"study_design_scores_gemma":[0.00001837494,0.0008971993,0.1666546,0.00002928411,0.00007465688,0.0007687967,0.0004417454,0.0008311371,0.8276352,0.0001030247,0.002525541,0.00002040628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954306,0.001747395,0.0008052086,0.00008987846,0.00001318776,0.000021063,0.001211131,0.00002352201,0.0006580253],"genre_scores_gemma":[0.9922793,0.001466098,0.00174923,0.0001364087,0.00003080958,0.00006629315,0.00246922,0.00001466535,0.001788096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007520814,"threshold_uncertainty_score":0.002515972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02163365918183101,"score_gpt":0.2766216348997924,"score_spread":0.2549879757179614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}