{"id":"W2120703037","doi":"10.1375/1369052042335269","title":"Pharmacogenetics of Nicotine Metabolism in Twins: Methods and Procedures","year":2004,"lang":"en","type":"article","venue":"Twin Research","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Research Resources; National Institute on Drug Abuse","keywords":"Zygosity; CYP2A6; Cotinine; Nicotine; Pharmacogenetics; Metabolite; Genotype; Drug metabolism; Medicine; Pharmacology; Pharmacokinetics; Twin study; Physiology; Metabolism; Drug; Genetics; Biology; Internal medicine; Heritability; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002295074,0.000068831,0.0001627743,0.00009117156,0.00003169871,0.00001286111,0.0001504652,0.00008878586,0.0005741722],"category_scores_gemma":[0.001543437,0.00005002562,0.00002672594,0.0002449958,0.0001502496,0.00002428913,0.0001026336,0.0002058622,0.000005486329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002668566,"about_ca_system_score_gemma":0.0001009095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001005223,"about_ca_topic_score_gemma":0.00001500409,"domain_scores_codex":[0.9988495,0.0001799016,0.0002158423,0.0002020097,0.0003240038,0.0002287031],"domain_scores_gemma":[0.9992938,0.0003614638,0.00003326708,0.0001296682,0.0001270801,0.00005472424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004788895,0.0001216738,0.003680847,0.0001215402,0.00001097714,0.000001089175,0.0001739615,0.00003193835,0.9571632,0.0003826801,0.00001804105,0.03824612],"study_design_scores_gemma":[0.0006333251,0.00002455198,0.02091074,0.00005437651,0.000007087932,0.000001916486,0.0001876821,0.0001509979,0.971534,0.005208299,0.001224505,0.00006249716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924558,0.003580824,0.00003711913,0.0002952275,0.0000103637,0.00009222921,0.000004065234,0.00001063294,0.003513713],"genre_scores_gemma":[0.9913384,0.0008214915,0.007598337,0.00001922667,0.00006813263,0.00002739799,0.000002767542,0.000007112984,0.0001170825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03818363,"threshold_uncertainty_score":0.6286783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1912067421631342,"score_gpt":0.5130750607108627,"score_spread":0.3218683185477286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}