{"id":"W2120703255","doi":"10.1002/jcph.436","title":"Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: In vitro and in vivo correlation","year":2014,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"CYP3A; CYP2B6; CYP2C9; Pharmacology; Midazolam; CYP3A4; In vivo; Pharmacokinetics; In vitro; CYP2D6; Protease inhibitor (pharmacology); Chemistry; Cytochrome P450; Biology; Virology; Microsome; Enzyme; Virus; Biochemistry; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001088887,0.0007599533,0.0007265419,0.0004552884,0.0002498633,0.0007263872,0.0004285703,0.0005086316,0.001519837],"category_scores_gemma":[0.001766674,0.0003825044,0.0005199857,0.000456558,0.000231352,0.0003947445,0.0002267113,0.0008710112,0.0005825765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006105949,"about_ca_system_score_gemma":0.0003323824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00161533,"about_ca_topic_score_gemma":0.00153956,"domain_scores_codex":[0.9985776,0.0008235346,0.00007518833,0.00015728,0.0002534849,0.0001129764],"domain_scores_gemma":[0.9987483,0.0006478276,0.000248909,0.000099891,0.0001652725,0.00008977995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007538807,0.001824207,0.03050192,0.0006861986,0.0008524712,0.0003424249,0.0001391495,0.007597678,0.8846788,0.0003602054,0.001198467,0.06427971],"study_design_scores_gemma":[0.0002031515,0.01447244,0.06533342,0.00005032352,0.0004763107,0.002032748,0.0001160247,0.03394625,0.8765881,0.0002290515,0.006486028,0.0000662206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966975,0.02018313,0.008390778,0.0002074634,0.0000872044,0.0001457519,0.0008652235,0.0001159861,0.003029345],"genre_scores_gemma":[0.9903668,0.004505646,0.002954961,0.00009810844,0.00005160519,0.00006035174,0.0009728288,0.00001814831,0.0009715276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00161533,"threshold_uncertainty_score":0.005758643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04768740136658928,"score_gpt":0.4200101933250173,"score_spread":0.372322791958428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}