{"id":"W2120706978","doi":"10.1158/1078-0432.ccr-08-2999","title":"A Phase I, Pharmacokinetic and Pharmacodynamic Study on Vorinostat in Combination with 5-Fluorouracil, Leucovorin, and Oxaliplatin in Patients with Refractory Colorectal Cancer","year":2009,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; Kimberly-Clark","keywords":"Vorinostat; Pharmacokinetics; Medicine; Oxaliplatin; FOLFOX; Pharmacology; Cmax; Fluorouracil; Leukopenia; Internal medicine; Gastroenterology; Colorectal cancer; Oncology; Chemotherapy; Cancer; Chemistry; Histone deacetylase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001301124,0.001309502,0.002069256,0.0004505105,0.0005225891,0.0007776113,0.0007086418,0.0008923273,0.001675551],"category_scores_gemma":[0.001122499,0.0006775944,0.001028901,0.0004863354,0.001183769,0.0007902489,0.0002284714,0.002508311,0.000438818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008684112,"about_ca_system_score_gemma":0.001600753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006629188,"about_ca_topic_score_gemma":0.001773779,"domain_scores_codex":[0.9993706,0.0003314038,0.00003176572,0.00009007729,0.00008043327,0.00009565095],"domain_scores_gemma":[0.9991245,0.0001964405,0.0002202617,0.00006244697,0.00004699816,0.0003493847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.561492,0.1016139,0.01564147,0.001277467,0.001880404,0.0008705739,0.000619505,0.004777244,0.1804135,0.0003172759,0.003109642,0.127987],"study_design_scores_gemma":[0.244939,0.725773,0.01641658,0.00002855344,0.0004592716,0.0005142205,0.00006467432,0.001553095,0.007958914,0.00008896478,0.002166046,0.00003769273],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965662,0.00143419,0.0003841172,0.0002401446,0.00006125242,0.0006037349,0.0001989976,0.00004039371,0.0004708982],"genre_scores_gemma":[0.9951738,0.000991734,0.001109715,0.0004132112,0.0001542117,0.000672444,0.0006988648,0.0000165577,0.0007695395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002069256,"threshold_uncertainty_score":0.006881058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05236298826956668,"score_gpt":0.4732157032925411,"score_spread":0.4208527150229744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}