{"id":"W2120706978","doi":"10.1158/1078-0432.ccr-08-2999","title":"A Phase I, Pharmacokinetic and Pharmacodynamic Study on Vorinostat in Combination with 5-Fluorouracil, Leucovorin, and Oxaliplatin in Patients with Refractory Colorectal Cancer","year":2009,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; Kimberly-Clark","keywords":"Vorinostat; Pharmacokinetics; Medicine; Oxaliplatin; FOLFOX; Pharmacology; Cmax; Fluorouracil; Leukopenia; Internal medicine; Gastroenterology; Colorectal cancer; Oncology; Chemotherapy; Cancer; Chemistry; Histone deacetylase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00129916,0.0001984695,0.0002929308,0.000253753,0.00009596707,0.00003637493,0.0001671934,0.0001209243,0.00002121899],"category_scores_gemma":[0.0001687067,0.0001609994,0.0000205173,0.0004411108,0.0003387039,0.00001983609,0.0001018314,0.0009272435,0.00000179484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001744236,"about_ca_system_score_gemma":0.0003040318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005460974,"about_ca_topic_score_gemma":0.001748916,"domain_scores_codex":[0.9969454,0.0007135937,0.0004002097,0.0007580484,0.0006844922,0.0004982228],"domain_scores_gemma":[0.9990287,0.0001801108,0.00007620037,0.0002118383,0.0002878066,0.0002153169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02055211,0.007913333,0.8140125,0.00003623335,0.00005672652,0.00008185997,0.0003494149,0.0000622778,0.02057062,0.000003263589,0.0003103954,0.1360513],"study_design_scores_gemma":[0.03992134,0.03212273,0.9170116,0.0001435211,0.00001570733,0.000001491354,0.0001496164,0.0004224,0.009209303,0.000007611456,0.0006931815,0.0003015167],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975629,0.0004412144,0.0000022529,0.0002817214,0.0000534691,0.001504079,0.00004222257,0.000007516118,0.0001045675],"genre_scores_gemma":[0.9987093,0.0006532202,0.00001652578,0.0000792985,0.00009695128,0.0002628732,0.00003909185,0.00002756358,0.0001151963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1357498,"threshold_uncertainty_score":0.6565365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05236298826956668,"score_gpt":0.4732157032925411,"score_spread":0.4208527150229744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}