{"id":"W2120708799","doi":"10.2217/fvl.14.48","title":"Identifying Roadblocks to sUccessful Oncolytic Virotherapy: What are they and how do we Approach Them?","year":2014,"lang":"en","type":"article","venue":"Future Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre","funders":"","keywords":"Oncolytic virus; Virotherapy; Medicine; Gain of function; Clinical trial; Milestone; Immune system; Cancer research; Immunology; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01106207,0.001224648,0.00239907,0.001020141,0.002500663,0.01173897,0.002293879,0.006555216,0.008670394],"category_scores_gemma":[0.01773824,0.0008195138,0.001112204,0.0009219943,0.008060935,0.01620102,0.002824185,0.01234792,0.003355862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003953252,"about_ca_system_score_gemma":0.01854248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004189821,"about_ca_topic_score_gemma":0.009726616,"domain_scores_codex":[0.9962418,0.001163219,0.0002973698,0.0003676231,0.0008791093,0.001050863],"domain_scores_gemma":[0.9822974,0.009700937,0.002263305,0.0005574494,0.003130483,0.002050339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001259888,0.001585599,0.01944698,0.009451749,0.0006899929,0.001466847,0.001753061,0.01138277,0.02006621,0.1877711,0.1613505,0.5837753],"study_design_scores_gemma":[0.0002287871,0.001355848,0.01322085,0.007571017,0.000795387,0.002374216,0.01826641,0.01155837,0.01833313,0.5382462,0.3875756,0.0004743104],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03530847,0.4621442,0.02584391,0.4558814,0.004290757,0.0002590677,0.0005295039,0.0005097606,0.01523301],"genre_scores_gemma":[0.3160157,0.5827851,0.03762866,0.04585273,0.005423178,0.0006710268,0.0008404995,0.0002641052,0.01051892],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01173897,"threshold_uncertainty_score":0.0585025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710549088539762,"score_gpt":0.2769586621648188,"score_spread":0.2598531712794212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}