{"id":"W2120781757","doi":"10.1039/c005066k","title":"Acyclic triaryl olefins possessing a sulfohydroxamic acid pharmacophore: synthesis, nitric oxide/nitroxyl release, cyclooxygenase inhibition, and anti-inflammatory studies","year":2010,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Moiety; Substituent; Nitroxyl; Nitric oxide; Cyclooxygenase; Pharmacophore; Ibuprofen; Stereochemistry; Anti-inflammatory; Medicinal chemistry; Organic chemistry; Enzyme; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001396807,0.0003832222,0.0002151182,0.0002180195,0.00009686836,0.0001158859,0.0002106082,0.0002602127,0.0006428383],"category_scores_gemma":[0.00008007838,0.000112907,0.0002230654,0.0002733373,0.0001233142,0.0002092894,0.000141132,0.0003195099,0.0002836934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001962451,"about_ca_system_score_gemma":0.0001504621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003600363,"about_ca_topic_score_gemma":0.0006750437,"domain_scores_codex":[0.9999435,0.000007298511,0.000005190713,0.00001092087,0.00001201695,0.00002102149],"domain_scores_gemma":[0.9999523,0.000004633328,0.0000149659,0.000004360382,0.000008331913,0.00001527673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001502643,0.00007989204,0.00008520098,0.0001206366,0.000008495096,0.0001365256,0.0000235222,0.000353109,0.9930199,0.0003788086,0.00006659205,0.005577049],"study_design_scores_gemma":[0.00003831324,0.001561894,0.001318789,0.0000109382,0.00003589152,0.000308715,0.00001616925,0.0004888134,0.9892973,0.0001002292,0.006808528,0.00001440326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692695,0.01115662,0.01256461,0.0001540127,0.00006927439,0.0001629109,0.0006198844,0.0001223404,0.005880862],"genre_scores_gemma":[0.9829993,0.006779777,0.006660417,0.00007172952,0.00002739718,0.00006006318,0.0005014527,0.00001631182,0.002883625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006428383,"threshold_uncertainty_score":0.002150476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008439963933622984,"score_gpt":0.2428147898805474,"score_spread":0.2343748259469244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}