{"id":"W2120813162","doi":"10.1139/o05-114","title":"H2AX: tailoring histone H2A for chromatin-dependent genomic integrity","year":2005,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research; Southwest Research Institute","keywords":"Chromatin; Histone; Biology; Genetics; Histone H2A; Cell biology; Epigenetics; Chromatin remodeling; Epigenomics; Computational biology; DNA; Gene; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004218921,0.0008834751,0.0009483452,0.001227183,0.0003162195,0.0006579963,0.000885162,0.0009695865,0.002800445],"category_scores_gemma":[0.0002371977,0.0002768533,0.0002131701,0.001761272,0.0005108801,0.001071039,0.0005557524,0.001079851,0.005396179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006477504,"about_ca_system_score_gemma":0.0004815554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007015246,"about_ca_topic_score_gemma":0.001012612,"domain_scores_codex":[0.9998909,0.00001287834,0.000009346169,0.00003019608,0.00004489992,0.00001170891],"domain_scores_gemma":[0.9999151,0.00002171873,0.00001724892,0.000005363443,0.00002370367,0.0000167972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001032515,0.00005240205,0.0002036568,0.007638642,0.00005978228,0.00032192,0.00007555465,0.00067454,0.02453443,0.005120416,0.02071261,0.9405029],"study_design_scores_gemma":[0.00001519258,0.0000550429,0.0006532028,0.0004216992,0.00003007014,0.001089692,0.0000356199,0.00007509981,0.003892969,0.001611931,0.9921064,0.00001312808],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005465635,0.9937823,0.0009893302,0.0002464626,0.0002599198,0.00001082508,0.00003147263,0.00003394605,0.004099153],"genre_scores_gemma":[0.00261613,0.9911702,0.001057084,0.0002537755,0.000189113,0.00001557699,0.0000670154,0.000007537429,0.004623607],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002800445,"threshold_uncertainty_score":0.00936836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02621551387044285,"score_gpt":0.303950199158276,"score_spread":0.2777346852878332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}