{"id":"W2120819444","doi":"10.1093/toxsci/kfu200","title":"Adverse Outcome Pathway Development II: Best Practices","year":2014,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada","funders":"","keywords":"Adverse Outcome Pathway; Outcome (game theory); Adverse effect; Medicine; Intensive care medicine; Internal medicine; Biology; Computational biology; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1211412,0.003294427,0.002222967,0.02126783,0.003496844,0.01979396,0.01466192,0.007127854,0.005881967],"category_scores_gemma":[0.1696789,0.002039804,0.003813401,0.01586026,0.00845269,0.01394771,0.009789911,0.009515005,0.007441938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01538069,"about_ca_system_score_gemma":0.03405767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01716699,"about_ca_topic_score_gemma":0.01509538,"domain_scores_codex":[0.9131255,0.03413764,0.01537176,0.006728387,0.02866491,0.001971817],"domain_scores_gemma":[0.8442376,0.05776024,0.01299874,0.02698196,0.05411904,0.003902391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001334135,0.0004313822,0.002855253,0.007855014,0.0003598642,0.000941867,0.004574279,0.01688137,0.001546001,0.234991,0.09617038,0.6332603],"study_design_scores_gemma":[0.00007301753,0.0001812384,0.001163184,0.02164832,0.0002699725,0.001033049,0.0028799,0.00945678,0.004469056,0.2707185,0.6878721,0.0002348665],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.003073169,0.02344941,0.8125988,0.07952454,0.00155764,0.003536742,0.002995125,0.005851555,0.06741308],"genre_scores_gemma":[0.01790715,0.01966178,0.9482671,0.004733943,0.0003406523,0.001495772,0.002670185,0.0006997052,0.0042237],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.1211412,"threshold_uncertainty_score":0.6406634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7262066663872818,"score_gpt":0.5083028589867884,"score_spread":0.2179038074004934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}