{"id":"W2120819444","doi":"10.1093/toxsci/kfu200","title":"Adverse Outcome Pathway Development II: Best Practices","year":2014,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada","funders":"","keywords":"Adverse Outcome Pathway; Outcome (game theory); Adverse effect; Medicine; Intensive care medicine; Internal medicine; Biology; Computational biology; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.02764336,0.0001661061,0.0006206507,0.0001567304,0.0009691641,0.00009832041,0.0005971034,0.0001521448,0.001865829],"category_scores_gemma":[0.01457376,0.0001493472,0.00007680899,0.0002895318,0.0003223316,0.0006177049,0.0001765941,0.0001593542,0.005921069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002524208,"about_ca_system_score_gemma":0.0001519153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001646821,"about_ca_topic_score_gemma":0.0001725629,"domain_scores_codex":[0.9957867,0.0003219159,0.002516193,0.0006835569,0.0001700195,0.0005215958],"domain_scores_gemma":[0.9953601,0.00147732,0.002648461,0.0002460951,0.00003277663,0.000235198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001197924,0.0006666784,0.4130217,0.00009845052,0.0000285305,0.00000231365,0.001808512,0.0003768551,0.00004586597,0.5742142,0.004910305,0.004814561],"study_design_scores_gemma":[0.0004233724,0.0006435521,0.0978098,0.00002440241,0.000003073605,0.000005348387,0.00109772,0.002455781,0.00005706064,0.01394366,0.8830649,0.0004712954],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8785031,0.0002668516,0.001233109,0.03229927,0.000675054,0.0003864346,0.00001372678,0.00008793287,0.08653451],"genre_scores_gemma":[0.9674417,0.00001434716,0.01528124,0.01392139,0.0002408411,0.00007901569,0.000003385428,0.00000704269,0.003011077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8781546,"threshold_uncertainty_score":0.9990466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7262066663872818,"score_gpt":0.5083028589867884,"score_spread":0.2179038074004934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}