{"id":"W2120820093","doi":"10.1093/neuonc/not035","title":"Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin","year":2013,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Alberta Innovates; Killam Trusts; Terry Fox Foundation; V Foundation for Cancer Research","keywords":"Oncolytic virus; Myxoma virus; In vivo; Neurosphere; Temozolomide; Biology; Virotherapy; Cancer research; Stem cell; In vitro; Population; Brain tumor; Glioma; Immunology; Medicine; Virus; Pathology; Cell biology; Tumor cells","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001902993,0.0004456719,0.000468244,0.0003690941,0.0001657327,0.0003889574,0.0002843129,0.0002707676,0.00066504],"category_scores_gemma":[0.0001012518,0.0001258478,0.0003400484,0.0002291824,0.0002268197,0.0001783357,0.0002130951,0.0004710648,0.0002575115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002543816,"about_ca_system_score_gemma":0.0002605799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004506634,"about_ca_topic_score_gemma":0.0009702368,"domain_scores_codex":[0.9998547,0.00002210493,0.00001836002,0.00003721709,0.00003862775,0.00002900273],"domain_scores_gemma":[0.999925,0.00001712583,0.00001785254,0.00001421369,0.00000748743,0.00001821863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002715863,0.0001526233,0.0009645784,0.0001167068,0.00004325535,0.00008392484,0.00004050471,0.0004276778,0.9907936,0.0001097737,0.0001247101,0.006871117],"study_design_scores_gemma":[0.00006692694,0.003090396,0.004875467,0.00001145363,0.0001107985,0.0009675185,0.00003561008,0.001459399,0.9855552,0.00003592824,0.003783082,0.000008228508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934102,0.003341449,0.001726795,0.00007882884,0.00003882614,0.00008483839,0.0001774004,0.00005994649,0.001081719],"genre_scores_gemma":[0.9937331,0.001589067,0.003748096,0.00002748649,0.00002437813,0.00007359738,0.0002870771,0.00001101973,0.0005061505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00066504,"threshold_uncertainty_score":0.002224803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02383856577493879,"score_gpt":0.3136653750383318,"score_spread":0.289826809263393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}