{"id":"W2120846782","doi":"10.1128/aac.03667-14","title":"Multiple Influenza A (H3N2) Mutations Conferring Resistance to Neuraminidase Inhibitors in a Bone Marrow Transplant Recipient","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Public Health Agency of Canada; University of Toronto; University Health Network","funders":"","keywords":"Zanamivir; Neuraminidase; Neuraminidase inhibitor; Virology; Oseltamivir; Viral quasispecies; Virus; Biology; Resistance mutation; Drug resistance; Influenza A virus; Sanger sequencing; Viral evolution; Mutation; Microbiology; Gene; Medicine; Genetics; Reverse transcriptase; Polymerase chain reaction; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002863789,0.0003968789,0.000388695,0.0004421514,0.0008261682,0.0004014452,0.0002844805,0.0004690165,0.001288557],"category_scores_gemma":[0.0003057821,0.0002265572,0.0003101921,0.0001811381,0.0002966814,0.000260817,0.0003381075,0.0006457361,0.0003366688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003096263,"about_ca_system_score_gemma":0.0002309577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009648536,"about_ca_topic_score_gemma":0.0008118137,"domain_scores_codex":[0.9998412,0.00002730829,0.00001584586,0.00004301932,0.00003293424,0.00003970878],"domain_scores_gemma":[0.9998734,0.00002084553,0.0000239232,0.00001017649,0.000009300536,0.00006225542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.004789821,0.002901816,0.3192892,0.0001646423,0.0001804973,0.2711765,0.002236008,0.0007770714,0.3628231,0.0007213113,0.001076034,0.03386402],"study_design_scores_gemma":[0.0002350661,0.01578466,0.5279541,0.0000543247,0.0003380801,0.3643294,0.002258907,0.004303655,0.08044752,0.0005497825,0.003672153,0.00007229198],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991886,0.0001805418,0.0001859436,0.00009327361,0.00001070607,0.00001158317,0.00002059191,0.00000741211,0.0003013331],"genre_scores_gemma":[0.9993524,0.0001134804,0.0001211081,0.00006552374,0.00001126795,0.000003631527,0.00002402612,0.000002394716,0.000306121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001288557,"threshold_uncertainty_score":0.004310668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03841123671620238,"score_gpt":0.3200734785427747,"score_spread":0.2816622418265723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}