{"id":"W2120846782","doi":"10.1128/aac.03667-14","title":"Multiple Influenza A (H3N2) Mutations Conferring Resistance to Neuraminidase Inhibitors in a Bone Marrow Transplant Recipient","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Public Health Agency of Canada; University of Toronto; University Health Network","funders":"","keywords":"Zanamivir; Neuraminidase; Neuraminidase inhibitor; Virology; Oseltamivir; Viral quasispecies; Virus; Biology; Resistance mutation; Drug resistance; Influenza A virus; Sanger sequencing; Viral evolution; Mutation; Microbiology; Gene; Medicine; Genetics; Reverse transcriptase; Polymerase chain reaction; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000241383,0.0002079056,0.0003618852,0.0002169367,0.0001428048,0.0000445884,0.00007387561,0.00007699297,0.00003643447],"category_scores_gemma":[0.0001044125,0.0001849677,0.00006755485,0.0002576399,0.0001106866,0.00007827234,0.00003325601,0.0001962931,0.0000199999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006229975,"about_ca_system_score_gemma":0.00003788175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001667664,"about_ca_topic_score_gemma":0.0003956045,"domain_scores_codex":[0.9985803,0.0000522804,0.000364295,0.0003740009,0.0002128909,0.0004162626],"domain_scores_gemma":[0.9993972,0.00007707915,0.00005592957,0.0002088708,0.00008157509,0.0001793838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004860563,0.0009459146,0.6009413,0.000602534,0.0002311326,0.0002166958,0.01696369,0.000104821,0.3236651,0.0001212954,0.02476909,0.02657781],"study_design_scores_gemma":[0.01442127,0.0004091395,0.5536618,0.001326387,0.00004886209,0.00003374068,0.0002496767,0.0005756617,0.0676455,0.00003706794,0.3610038,0.0005870427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937565,0.00006630601,0.00008449646,0.004713041,0.00007099731,0.0006808428,0.00003156502,0.00004152333,0.0005546694],"genre_scores_gemma":[0.9795527,0.000266896,0.0007904609,0.0188292,0.00009052598,0.00003697016,0.00001298221,0.00003282416,0.0003874552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3362347,"threshold_uncertainty_score":0.7542764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03841123671620238,"score_gpt":0.3200734785427747,"score_spread":0.2816622418265723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}