{"id":"W2120846842","doi":"10.1111/j.1751-7915.2011.00267.x","title":"Directed evolution, natural products for cancer chemotherapy, and micro‐biosensing robots","year":2011,"lang":"en","type":"article","venue":"Microbial Biotechnology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Computational biology; Synthetic biology; Bacillus subtilis; Biology; Escherichia coli; Plasmid; Restriction enzyme; Cloning (programming); Gene; Biotechnology; Genetics; Computer science; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005462558,0.0001552454,0.0001450046,0.00007939022,0.0001175051,0.00001163407,0.0001224149,0.0002684955,0.000005891779],"category_scores_gemma":[0.00004830722,0.0001446221,0.00004383372,0.000126714,0.0002403017,0.000003675928,0.000107627,0.00009846133,0.000002947137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004957774,"about_ca_system_score_gemma":0.00008806558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006297848,"about_ca_topic_score_gemma":0.001016683,"domain_scores_codex":[0.9989854,0.00001732964,0.0001185615,0.0004545522,0.00003341772,0.0003907964],"domain_scores_gemma":[0.9995603,0.000003187935,0.00005091773,0.0002421392,0.0001095762,0.00003388954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003201636,0.00005608705,0.0004727324,0.00001963104,0.000108302,0.000002106921,0.00002995409,9.973697e-8,0.9851673,0.00004819681,0.002495014,0.01128039],"study_design_scores_gemma":[0.001078766,0.0002217318,0.00166199,0.00001191382,0.000016441,0.00004570355,0.00001183341,0.000005392149,0.9809072,0.00008628234,0.01579249,0.0001602617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917817,0.005510948,0.0003320241,0.001456094,0.0002250816,0.0005147964,0.00007203715,0.0000766389,0.00003069714],"genre_scores_gemma":[0.9920016,0.0006221521,0.006485973,0.0001576596,0.0001335404,0.00003932808,0.00008021652,0.00002667426,0.0004528404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01329747,"threshold_uncertainty_score":0.5897518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208250319814504,"score_gpt":0.2502405326686015,"score_spread":0.2381580294704565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}