{"id":"W2120877221","doi":"10.1177/1087057110363823","title":"AlphaScreen®-Based Characterization of the Bifunctional Kinase/RNase IRE1α: A Novel and Atypical Drug Target","year":2010,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"PerkinElmer Biosignal","funders":"","keywords":"Drug discovery; Autophosphorylation; Endoribonuclease; Endoplasmic reticulum; High-throughput screening; Druggability; Biology; Biochemistry; Protein kinase domain; Bifunctional; Computational biology; Cell biology; RNase P; Kinase; Chemistry; Protein kinase A; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005758549,0.0001119187,0.00009281886,0.00001965269,0.00006852833,0.00002950713,0.0001068668,0.00007495622,0.00002979374],"category_scores_gemma":[0.00008572067,0.00007949254,0.0000954114,0.00005404451,0.0001813244,0.00001085498,0.0000793823,0.00009025772,0.000001256637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003108586,"about_ca_system_score_gemma":0.0001097253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001292386,"about_ca_topic_score_gemma":0.00002549664,"domain_scores_codex":[0.9993494,0.00002113713,0.0001452479,0.0002241077,0.0001350501,0.0001250732],"domain_scores_gemma":[0.9995199,0.00001312162,0.00008616103,0.0002703393,0.00004348612,0.00006695102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002676822,0.0001443909,0.03401084,0.00002070374,0.00001747242,8.108665e-7,0.000006627813,0.0000206085,0.9639958,0.001170184,0.0002445194,0.0001004272],"study_design_scores_gemma":[0.001170416,0.00006330271,0.2644957,0.00002272243,0.00003445399,0.000006838306,0.00001739751,0.0005559227,0.7255605,0.0001196685,0.007778424,0.0001746123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996112,0.00004871127,0.002646004,0.0002864355,0.0003025126,0.0001237254,0.0003203154,0.000005103577,0.0001552178],"genre_scores_gemma":[0.9985564,0.000009363988,0.0002047808,0.0002953035,0.0001738833,0.00001532087,0.0003221629,0.00001243232,0.0004103028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2384352,"threshold_uncertainty_score":0.3241612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00364782427533406,"score_gpt":0.2000491909587979,"score_spread":0.1964013666834638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}