{"id":"W2120887281","doi":"10.1124/mol.111.072504","title":"Batrachotoxin, Pyrethroids, and BTG 502 Share Overlapping Binding Sites on Insect Sodium Channels","year":2011,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Batrachotoxin; Chemistry; Sodium channel; Stereochemistry; Helix (gastropod); Pyrethroid; Binding site; Gating; Sodium; Crystallography; Biophysics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001809082,0.0002502986,0.0004559126,0.0002368777,0.0003753738,0.0004838957,0.0002981881,0.0004306418,0.001845113],"category_scores_gemma":[0.0002907826,0.0002687538,0.0003955999,0.0002408715,0.0002791987,0.0002908527,0.0003697154,0.0002994972,0.0006008295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00061045,"about_ca_system_score_gemma":0.0003466579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002978973,"about_ca_topic_score_gemma":0.004834259,"domain_scores_codex":[0.9996845,0.00005347935,0.00001554424,0.00005659324,0.0001205249,0.00006950943],"domain_scores_gemma":[0.9998444,0.00003798949,0.00004291644,0.000013797,0.00002463633,0.0000362275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003664667,0.00002132952,0.00104023,0.00004124152,0.00001974321,0.00008886532,0.00003588577,0.0002184225,0.9949911,0.0004915991,0.00006657761,0.002618527],"study_design_scores_gemma":[0.00008934976,0.0003760973,0.1279133,0.0000186523,0.00005522505,0.00155534,0.0001574632,0.004912972,0.8596832,0.0008588747,0.004343014,0.00003649046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876713,0.001712279,0.006198234,0.000120967,0.00001657354,0.00003091713,0.0001837137,0.00008592164,0.003980103],"genre_scores_gemma":[0.9930101,0.0006409755,0.002969512,0.0001188265,0.000008014196,0.00002752888,0.0004160332,0.00001255275,0.002796394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002978973,"threshold_uncertainty_score":0.006172538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03816652952709572,"score_gpt":0.2707980131798255,"score_spread":0.2326314836527298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}