{"id":"W2120887281","doi":"10.1124/mol.111.072504","title":"Batrachotoxin, Pyrethroids, and BTG 502 Share Overlapping Binding Sites on Insect Sodium Channels","year":2011,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Batrachotoxin; Chemistry; Sodium channel; Stereochemistry; Helix (gastropod); Pyrethroid; Binding site; Gating; Sodium; Crystallography; Biophysics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698937,0.0002320236,0.000174328,0.0001448994,0.0001467543,0.00002435366,0.000133055,0.0002458755,0.000486953],"category_scores_gemma":[0.00005725167,0.0002406997,0.00009192928,0.0001204246,0.00009712717,0.000009906539,0.0001118661,0.0001703801,0.00004489506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002181736,"about_ca_system_score_gemma":0.0000315354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009304043,"about_ca_topic_score_gemma":0.00000169965,"domain_scores_codex":[0.9987024,0.0001246951,0.0002066068,0.0005040517,0.0001209334,0.00034128],"domain_scores_gemma":[0.9994856,0.00001594185,0.00009501019,0.0001767175,0.00009266312,0.0001341015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002252067,0.00007963464,0.0004776634,0.00002213184,0.00009057772,0.00003088812,0.0001724394,0.00007754135,0.9940099,0.0001555015,0.004013183,0.0006453807],"study_design_scores_gemma":[0.001140823,0.000536766,0.0009463303,0.000009673469,0.00003977092,0.00004319796,0.00006707886,0.0008555904,0.9817269,0.00009323157,0.01424231,0.0002983384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936492,0.0004478372,0.001633994,0.0001920653,0.001425481,0.0003108504,0.00002021004,0.00004589329,0.002274465],"genre_scores_gemma":[0.9962919,0.0001149411,0.0001816176,0.00203368,0.0005824688,0.00005541162,0.0002140132,0.00004059454,0.0004853099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01228296,"threshold_uncertainty_score":0.9815447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03816652952709572,"score_gpt":0.2707980131798255,"score_spread":0.2326314836527298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}