{"id":"W2120898338","doi":"10.1073/pnas.0236048100","title":"<i>kep1</i> interacts genetically with <i>dredd</i> / <i>Caspase-8</i> , and <i>kep1</i> mutants alter the balance of <i>dredd</i> isoforms","year":2003,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Mutant; Biology; Apoptosis; Gene isoform; Molecular biology; Cell biology; RNA; Caspase; Transfection; Wild type; RNA interference; Gene; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008393743,0.0003904401,0.0001614716,0.0001872872,0.0001786177,0.0002654286,0.0002548023,0.0003120025,0.001984745],"category_scores_gemma":[0.0001266652,0.0002448549,0.0002354394,0.0001202481,0.0002756878,0.0002242538,0.0002505852,0.0005513857,0.0007311646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004640335,"about_ca_system_score_gemma":0.0001162513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004567637,"about_ca_topic_score_gemma":0.0009242442,"domain_scores_codex":[0.999891,0.00001471077,0.000009951794,0.00003366141,0.00002460322,0.00002616383],"domain_scores_gemma":[0.9998149,0.00003259646,0.00007962465,0.00001878655,0.000007915973,0.00004619013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004011112,0.000007468832,0.0001253199,0.00001083906,0.000002555573,0.00003167862,0.000003860291,0.00002785553,0.999479,0.0000436944,0.00001318933,0.0002144592],"study_design_scores_gemma":[0.00001040764,0.00005126228,0.005274041,0.000004761891,0.00000972387,0.000398303,0.00001767207,0.0005656413,0.9926326,0.00004047403,0.0009908599,0.000004279309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974139,0.0003420027,0.00111751,0.00005242439,0.000008526446,0.000005347767,0.0002099193,0.00004599737,0.0008044186],"genre_scores_gemma":[0.9958456,0.000248909,0.001085846,0.00005309094,0.000004596998,0.0000128037,0.0006462461,0.000051439,0.002051472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001984745,"threshold_uncertainty_score":0.006639659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01911841307047065,"score_gpt":0.2901707910622229,"score_spread":0.2710523779917523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}