{"id":"W2120908143","doi":"10.4049/jimmunol.1000782","title":"Direct Comparison of Dll1- and Dll4-Mediated Notch Activation Levels Shows Differential Lymphomyeloid Lineage Commitment Outcomes","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto","funders":"National Institute on Aging; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Lymphopoiesis; Lineage (genetic); Haematopoiesis; Myeloid; Biology; Cell biology; Notch signaling pathway; Transcription factor; Function (biology); Cancer research; Gene; Stem cell; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003134405,0.0001138502,0.000265196,0.00005561562,0.00007852541,0.000004970624,0.0001805727,0.0001943591,0.00003155603],"category_scores_gemma":[0.0001100939,0.0000723197,0.00005954605,0.00004169739,0.0002209731,0.000006165918,0.00009585155,0.0001728352,0.000001565242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009924649,"about_ca_system_score_gemma":0.00005241356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009225463,"about_ca_topic_score_gemma":0.00003332144,"domain_scores_codex":[0.9991803,0.0001470462,0.000388653,0.00008375206,0.00007926165,0.0001209629],"domain_scores_gemma":[0.9991969,0.0001000685,0.0004162265,0.0001568035,0.0001051515,0.0000248138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003418397,0.00008660725,0.03429111,0.000003839556,0.0002427549,2.431739e-7,0.0001813922,0.000005997303,0.9595218,0.0000147425,0.0000793215,0.005230343],"study_design_scores_gemma":[0.0006371044,0.0002421175,0.3474292,0.000005211791,0.00002580793,0.0000282596,0.0000874196,0.00001336832,0.650552,0.00001330036,0.0009118276,0.00005446061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982308,0.0003660359,0.0004470882,0.00032957,0.0004421883,0.00009056625,0.00000861521,0.000002683777,0.00008245592],"genre_scores_gemma":[0.9993303,0.0001249902,0.0002382223,0.00006397908,0.00007361614,0.000001560094,0.00003607974,0.000007003803,0.0001242413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.313138,"threshold_uncertainty_score":0.2949112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01290618750977579,"score_gpt":0.2681578818536133,"score_spread":0.2552516943438375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}