{"id":"W2120934046","doi":"10.1128/mcb.23.23.8862-8877.2003","title":"mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription Factor UBF†","year":2003,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":459,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Ribosome biogenesis; Biology; P70-S6 Kinase 1; Cell biology; Transcription factor; Molecular biology; PI3K/AKT/mTOR pathway; Transcription (linguistics); Ribosomal s6 kinase; Ribosome; Signal transduction; Gene; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002193291,0.0001650826,0.0002033822,0.00003582306,0.00006828735,0.000005431234,0.0001323595,0.000296801,0.00001753886],"category_scores_gemma":[0.00004100754,0.0001233213,0.0001201204,0.0001028696,0.0003241457,0.000009254823,0.00002641242,0.00009091594,8.874704e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001941989,"about_ca_system_score_gemma":0.00005148177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005602574,"about_ca_topic_score_gemma":0.000007704341,"domain_scores_codex":[0.9986859,0.0003193785,0.0003660917,0.0003058831,0.0001720854,0.0001506768],"domain_scores_gemma":[0.9992741,0.00001199836,0.0002962033,0.0002842509,0.00009949458,0.00003393462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001121784,0.00004105825,0.002883379,0.00004210453,0.00006414582,1.719588e-7,0.0002721835,0.00002386273,0.9958035,0.0003257245,0.00001451376,0.0004171505],"study_design_scores_gemma":[0.0007259654,0.0002386787,0.004450312,0.00002622208,0.00005576271,0.000005966874,0.00005304747,0.00006040197,0.9928933,0.0005792323,0.0007903787,0.0001207662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884822,0.002824547,0.007978592,0.00009743399,0.0001548999,0.0003037741,0.0001108997,0.000003660867,0.00004392744],"genre_scores_gemma":[0.9994524,0.0001321756,0.0001517468,0.000070829,0.00002194328,0.000009358915,0.0001165369,0.00001757438,0.00002749843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01097007,"threshold_uncertainty_score":0.5028896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007217244854405168,"score_gpt":0.2102074486676538,"score_spread":0.2029902038132486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}