{"id":"W2120982899","doi":"10.1128/jvi.07244-11","title":"The H275Y Neuraminidase Mutation of the Pandemic A/H1N1 Influenza Virus Lengthens the Eclipse Phase and Reduces Viral Output of Infected Cells, Potentially Compromising Fitness in Ferrets","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; Compute Canada","keywords":"Neuraminidase; Biology; Virology; Oseltamivir; Virus; Mutant; Strain (injury); Microbiology; Mutation; Viral replication; Resistance mutation; Gene; RNA; Coronavirus disease 2019 (COVID-19); Reverse transcriptase; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130697,0.0003307418,0.0002736966,0.0001999246,0.0001560375,0.0002779316,0.0002683651,0.0002222146,0.0004793408],"category_scores_gemma":[0.0001998911,0.0001480852,0.0004744703,0.00007106906,0.0001745518,0.0001756913,0.000164276,0.0002953043,0.0001562449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008885289,"about_ca_system_score_gemma":0.0003289105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00395648,"about_ca_topic_score_gemma":0.00283851,"domain_scores_codex":[0.9999083,0.0000133618,0.000006032282,0.00002251724,0.00002343585,0.00002626293],"domain_scores_gemma":[0.9998909,0.00003242986,0.00004120987,0.000009599266,0.00000873155,0.00001705474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001947862,0.00007476192,0.002460975,0.00003653867,0.00001888843,0.00005583785,0.00001656591,0.003520868,0.9919302,0.0002614268,0.00005292175,0.001376232],"study_design_scores_gemma":[0.0000270121,0.000965948,0.02304961,0.00001020331,0.00005120768,0.0002884543,0.00006609125,0.04949812,0.9249472,0.0002849657,0.000792117,0.00001905348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983681,0.0001094723,0.001183418,0.00001928302,0.000003665398,0.000003135468,0.00008078077,0.000009707732,0.0002224585],"genre_scores_gemma":[0.9981039,0.0001529196,0.0009162098,0.000008492566,0.000003355672,0.00000932645,0.0001516972,0.000006869126,0.0006472947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00395648,"threshold_uncertainty_score":0.007866859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07842458024644079,"score_gpt":0.3894194178609571,"score_spread":0.3109948376145163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}