{"id":"W2120982899","doi":"10.1128/jvi.07244-11","title":"The H275Y Neuraminidase Mutation of the Pandemic A/H1N1 Influenza Virus Lengthens the Eclipse Phase and Reduces Viral Output of Infected Cells, Potentially Compromising Fitness in Ferrets","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; Compute Canada","keywords":"Neuraminidase; Biology; Virology; Oseltamivir; Virus; Mutant; Strain (injury); Microbiology; Mutation; Viral replication; Resistance mutation; Gene; RNA; Coronavirus disease 2019 (COVID-19); Reverse transcriptase; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001833896,0.0001608719,0.0004914501,0.0001719928,0.0001985697,0.00001547346,0.0002555229,0.0001228141,0.000009720331],"category_scores_gemma":[0.001263499,0.00007579849,0.0001350275,0.0002061925,0.0009165587,0.0001760799,0.000160157,0.0007692864,0.000001200025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005520424,"about_ca_system_score_gemma":0.0001601109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006054237,"about_ca_topic_score_gemma":0.00003796579,"domain_scores_codex":[0.997472,0.0007146004,0.0009071436,0.0001066661,0.0004324229,0.0003671704],"domain_scores_gemma":[0.9974973,0.0009523671,0.0008835166,0.0002496112,0.0003339249,0.00008334908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004309551,0.0007204362,0.05513872,0.00009643874,0.0004024105,0.00004547252,0.00725813,0.0003994315,0.9086211,0.00006339714,0.000180445,0.02276445],"study_design_scores_gemma":[0.01312327,0.002374811,0.8651759,0.0002615791,0.000525356,0.0009325481,0.001972112,0.0009540814,0.1111193,0.0003711182,0.003000852,0.0001890277],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952695,0.003059858,0.00001697304,0.0007600676,0.0004052104,0.0004205363,0.00001191145,0.000004285081,0.00005167061],"genre_scores_gemma":[0.998624,0.000642626,0.00004229641,0.0003699951,0.0002853553,0.000006492843,6.817373e-7,0.00001405198,0.00001444609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8100372,"threshold_uncertainty_score":0.3377099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07842458024644079,"score_gpt":0.3894194178609571,"score_spread":0.3109948376145163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}