{"id":"W2120987375","doi":"10.1152/ajpregu.00187.2014","title":"Autophagy is essential to support skeletal muscle plasticity in response to endurance exercise","year":2014,"lang":"en","type":"review","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Autophagy; Mitophagy; mTORC1; Skeletal muscle; Cell biology; Lysosome; Endurance training; Biology; Proteasome; Protein turnover; Protein degradation; Ubiquitin; Signal transduction; PI3K/AKT/mTOR pathway; Endocrinology; Protein biosynthesis; Biochemistry; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003955233,0.00101455,0.006944546,0.000881841,0.0001191031,0.00001896916,0.0005488674,0.0002691699,0.0003274594],"category_scores_gemma":[0.0001314047,0.0007041907,0.0009485862,0.0008422154,0.001339165,0.0001262919,0.0001759331,0.001166595,0.0001403431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372647,"about_ca_system_score_gemma":0.000922551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003397347,"about_ca_topic_score_gemma":0.00000899333,"domain_scores_codex":[0.9948251,0.001557418,0.001586187,0.000982596,0.0003465081,0.0007022451],"domain_scores_gemma":[0.9959422,0.000878324,0.001492544,0.0005323403,0.0004728058,0.000681725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02742912,0.002631944,0.00003367268,0.002979154,0.004037269,0.0002343641,0.01275484,0.0001529903,0.332524,0.0008971886,0.01178725,0.6045382],"study_design_scores_gemma":[0.005801973,0.03914391,0.211988,0.02083371,0.002747969,0.0004853458,0.003537543,0.00009365949,0.008980609,0.0009844562,0.7025849,0.002817989],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8361291,0.1619207,0.0001651671,0.0001328018,0.0003540605,0.001101416,0.0001212801,0.00002358006,0.00005189667],"genre_scores_gemma":[0.7984143,0.1984767,0.0005587875,0.001467953,0.0006186435,0.0001784726,0.00004179031,0.00006769056,0.0001756611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6907976,"threshold_uncertainty_score":0.9995409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02763338985819283,"score_gpt":0.358023073993954,"score_spread":0.3303896841357611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}