{"id":"W2121026738","doi":"10.3390/v4091711","title":"Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants?","year":2012,"lang":"en","type":"review","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Viremia; Human leukocyte antigen; Immunology; Biology; Context (archaeology); Immune system; Evasion (ethics); CD8; Virology; Virus; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002118993,0.0009631587,0.001742886,0.000329066,0.0009999517,0.0002844529,0.0009000103,0.0009952456,0.005701537],"category_scores_gemma":[0.00006330557,0.0007213904,0.0004634463,0.0004279841,0.0006101757,0.00111041,0.0003159032,0.001331828,0.01548617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004864291,"about_ca_system_score_gemma":0.0003329622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002202227,"about_ca_topic_score_gemma":0.0001945852,"domain_scores_codex":[0.9955803,0.001171325,0.000877445,0.001008946,0.0002092987,0.001152721],"domain_scores_gemma":[0.9977498,0.0003751219,0.0006591108,0.000952912,0.0001538987,0.0001091317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001409453,0.0008391904,0.0001492554,0.0009607008,0.003536176,0.00005134616,0.001110715,4.688705e-7,0.3071407,0.0004569979,0.01029961,0.6753138],"study_design_scores_gemma":[0.0007969778,0.0002569647,0.0005346873,0.002127077,0.0005140506,0.0000256469,0.00008556211,2.514255e-7,0.006594428,0.00007754009,0.9882156,0.0007711872],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009581666,0.9843142,0.000006253556,0.00002917635,0.001260285,0.001124221,0.003120595,0.0001639753,0.0003996156],"genre_scores_gemma":[0.01982363,0.9650147,0.00003275708,0.00006232905,0.0001626636,0.0001091385,0.00977011,0.0001083392,0.004916325],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.977916,"threshold_uncertainty_score":0.9995237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09779440716620771,"score_gpt":0.3575318601782831,"score_spread":0.2597374530120754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}