{"id":"W2121026738","doi":"10.3390/v4091711","title":"Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants?","year":2012,"lang":"en","type":"review","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Viremia; Human leukocyte antigen; Immunology; Biology; Context (archaeology); Immune system; Evasion (ethics); CD8; Virology; Virus; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005292156,0.0005876499,0.001035672,0.001141023,0.000193213,0.0007412445,0.0007117958,0.0009179159,0.001449161],"category_scores_gemma":[0.000570496,0.0002153839,0.0002506069,0.001332417,0.0005169991,0.001259409,0.0003877653,0.001325346,0.001386287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004594215,"about_ca_system_score_gemma":0.000677507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008487037,"about_ca_topic_score_gemma":0.00150495,"domain_scores_codex":[0.9998782,0.000023577,0.00001793202,0.00002183987,0.00004540691,0.00001313983],"domain_scores_gemma":[0.9997857,0.00008606091,0.0000299371,0.000007741922,0.00006517975,0.00002538842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008522984,0.00004862325,0.0002198531,0.007792537,0.00004712394,0.000172686,0.00005304294,0.0001750655,0.001858549,0.002330102,0.02388152,0.9633358],"study_design_scores_gemma":[0.00001987273,0.0001108395,0.001246448,0.001750764,0.00005456031,0.00164761,0.00007853569,0.00007811559,0.0005561958,0.001538968,0.9929017,0.00001625258],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001249827,0.9988288,0.00006028193,0.0002972258,0.0001787879,0.00000172238,0.000006423716,0.000003499712,0.0004982236],"genre_scores_gemma":[0.0005506382,0.9986269,0.0001075293,0.0001755766,0.000147106,0.000003164897,0.00001146066,7.673e-7,0.0003767732],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001449161,"threshold_uncertainty_score":0.004847944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09779440716620771,"score_gpt":0.3575318601782831,"score_spread":0.2597374530120754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}