{"id":"W2121036626","doi":"10.1080/000155500750042808","title":"Hypothesis: The epidermal permeability barrier is a porous medium","year":2000,"lang":"en","type":"review","venue":"Acta Dermato Venereologica","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Stratum corneum; Permeability (electromagnetism); Corneocyte; Permeation; Membrane; Biophysics; Porous medium; Chemistry; Porosity; Intracellular; Materials science; Chemical engineering; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.001351672,0.001457002,0.002782604,0.0002076831,0.00103706,0.00006982949,0.002661574,0.00218533,0.0253446],"category_scores_gemma":[0.0003986628,0.0009334841,0.001302242,0.0005234618,0.001527623,0.0002557167,0.0004491495,0.003831404,0.00242164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002912444,"about_ca_system_score_gemma":0.0006317446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001436478,"about_ca_topic_score_gemma":0.000007089162,"domain_scores_codex":[0.9904719,0.004020473,0.00185038,0.001445048,0.0005753545,0.001636866],"domain_scores_gemma":[0.9928633,0.0040919,0.0007786014,0.001646609,0.0001048936,0.0005146867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001115759,0.0004178924,0.00009320868,0.003152542,0.00119897,0.0003873464,0.0004944729,0.00002319389,0.000006040605,0.00004979324,0.04347216,0.9505928],"study_design_scores_gemma":[0.00051069,0.00005234072,0.00003838016,0.0005586199,0.002653976,0.0008767738,0.00006139771,0.00004239347,0.00007156459,0.0005280083,0.9935985,0.001007313],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004366814,0.9835428,0.00001425073,0.002054026,0.001488206,0.002211871,0.0008564698,0.0003320481,0.009063665],"genre_scores_gemma":[0.004371313,0.9768023,0.0001481528,0.01428204,0.0007375354,0.0009958831,0.0001639458,0.000154497,0.002344275],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9501264,"threshold_uncertainty_score":0.999818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1983861644482652,"score_gpt":0.4382682726477037,"score_spread":0.2398821081994385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}