{"id":"W2121052402","doi":"10.1160/th13-08-0672","title":"A novel thromboxane A2 receptor N42S variant results in reduced surface expression and platelet dysfunction","year":2014,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; British Heart Foundation; Wellcome Trust","keywords":"Thromboxane receptor; Platelet; Thromboxane; Thromboxane A2; Receptor; Endocrinology; Internal medicine; G protein-coupled receptor; Platelet activation; Biology; Receptor expression; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162781,0.0004606044,0.0002584353,0.0002945059,0.00024757,0.0003209457,0.0001901379,0.0005680034,0.002083474],"category_scores_gemma":[0.0003953807,0.0001141563,0.0003643001,0.0002370625,0.0002782126,0.0001257584,0.000240417,0.0003120016,0.000453335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001332776,"about_ca_system_score_gemma":0.0001074791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006203919,"about_ca_topic_score_gemma":0.0006144178,"domain_scores_codex":[0.9998114,0.00002298066,0.00002548285,0.0000649522,0.00005005427,0.00002518596],"domain_scores_gemma":[0.9998511,0.00003968993,0.00004231754,0.00001676694,0.00001911629,0.00003103076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001358008,0.0002398032,0.06881288,0.0001347632,0.0001560113,0.1582962,0.000563696,0.0003787465,0.7511111,0.0007954317,0.001255975,0.0168974],"study_design_scores_gemma":[0.000144553,0.002136396,0.2518404,0.0000493511,0.0001605822,0.594825,0.0003680858,0.002043791,0.1365821,0.0005224312,0.01127196,0.00005533559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976042,0.0003326016,0.0005997564,0.000123551,0.00002028318,0.00001170555,0.0002781806,0.00002242426,0.001007272],"genre_scores_gemma":[0.998284,0.0001696353,0.0003638108,0.0001089327,0.00002432302,0.000006552574,0.0002798451,0.00001257879,0.0007501935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002083474,"threshold_uncertainty_score":0.006969929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03020220690620293,"score_gpt":0.2663011293129143,"score_spread":0.2360989224067113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}