{"id":"W2121058501","doi":"10.1016/s0022-3565(24)38985-2","title":"Pharmacological and Molecular Characterization of Muscarinic Receptor Subtypes in Human Esophageal Smooth Muscle","year":2000,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Methoctramine; Muscarinic acetylcholine receptor; Pirenzepine; Carbachol; Internal medicine; Muscarinic antagonist; Endocrinology; Biology; Receptor; Muscarinic acetylcholine receptor M2; Receptor antagonist; Muscle contraction; Muscarinic acetylcholine receptor M3; Antagonist; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000248924,0.0001425653,0.0003148192,0.0003113398,0.0003079978,0.0002597304,0.0002169468,0.0002871961,0.001990339],"category_scores_gemma":[0.0004411261,0.0001972236,0.0003852164,0.0002456054,0.000210868,0.0002520279,0.000176024,0.0004833468,0.0005619132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001588804,"about_ca_system_score_gemma":0.0002457366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001448802,"about_ca_topic_score_gemma":0.00163617,"domain_scores_codex":[0.99988,0.00002628148,0.00001461329,0.00002465044,0.00001985299,0.00003458397],"domain_scores_gemma":[0.999887,0.00004081795,0.00001024764,0.00001975767,0.00002051469,0.00002171102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009369473,0.00006809374,0.001682566,0.00006373905,0.00003107161,0.0002315234,0.00007661177,0.0000652458,0.9919655,0.0002375608,0.0001013976,0.004539747],"study_design_scores_gemma":[0.0002873208,0.003775836,0.1947614,0.00004475291,0.000463433,0.007400509,0.0008363724,0.002396705,0.7767445,0.0005531955,0.0127045,0.00003147899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894062,0.005010268,0.002757587,0.0002119705,0.00002428001,0.00006772369,0.0005624032,0.00001741257,0.001942215],"genre_scores_gemma":[0.9881107,0.00268247,0.003092691,0.0002063608,0.00004514276,0.00009792024,0.002309876,0.00001595135,0.003438891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001990339,"threshold_uncertainty_score":0.006658375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01392245883149588,"score_gpt":0.3051446705922567,"score_spread":0.2912222117607608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}