{"id":"W2121090593","doi":"10.1101/gad.245233.114","title":"Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon","year":2014,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nutrasource","funders":"Japan Science and Technology Agency; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Biology; Stem cell; Epithelium; Intestinal epithelium; Organoid; Cell biology; Regeneration (biology); Transplantation; Gastrointestinal tract; Cell; Paneth cell; Adult stem cell; Cancer research; Immunology; Cellular differentiation; Small intestine; Internal medicine; Genetics; Endocrinology; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004850415,0.0002111325,0.0002865052,0.00008259567,0.0001011262,0.00003752286,0.0001410003,0.00005779221,0.0002157556],"category_scores_gemma":[0.000005821249,0.0001361002,0.00005771382,0.0002073908,0.0000692102,0.00004113794,0.00009048684,0.0001735194,0.00007593802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002433881,"about_ca_system_score_gemma":0.00035605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002998164,"about_ca_topic_score_gemma":0.003018115,"domain_scores_codex":[0.998463,0.00008132182,0.0003663716,0.0003572561,0.0003844626,0.0003475962],"domain_scores_gemma":[0.9992872,0.00006085609,0.0001069993,0.0002731479,0.000131739,0.0001400656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.005533343,0.001837519,0.3528999,0.001408298,0.0006437178,0.0002890299,0.008919744,0.0005459257,0.2312056,0.001110371,0.005808552,0.3897979],"study_design_scores_gemma":[0.004329445,0.0006928309,0.4393309,0.0002564343,0.0001555512,0.00009985824,0.0006851267,0.000119001,0.2983097,0.0001549176,0.2553695,0.0004967359],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833151,0.000259752,0.01361293,0.001035493,0.0002630233,0.0007354139,0.00000426334,0.00003652101,0.0007375742],"genre_scores_gemma":[0.9794123,0.00008897703,0.01453771,0.002392584,0.0001476504,0.0002049778,0.00002654223,0.00002826027,0.003161024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3893012,"threshold_uncertainty_score":0.5550006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02479853143400912,"score_gpt":0.2217934021406104,"score_spread":0.1969948707066013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}