{"id":"W2121090593","doi":"10.1101/gad.245233.114","title":"Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon","year":2014,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nutrasource","funders":"Japan Science and Technology Agency; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Biology; Stem cell; Epithelium; Intestinal epithelium; Organoid; Cell biology; Regeneration (biology); Transplantation; Gastrointestinal tract; Cell; Paneth cell; Adult stem cell; Cancer research; Immunology; Cellular differentiation; Small intestine; Internal medicine; Genetics; Endocrinology; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001310474,0.0001543554,0.0001789392,0.0002268104,0.0001177416,0.0002802566,0.000138282,0.0002040503,0.001016269],"category_scores_gemma":[0.0001068603,0.000122765,0.0001470977,0.0001314745,0.0002132055,0.0002479645,0.0001682443,0.0006236816,0.0003628467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001083438,"about_ca_system_score_gemma":0.0001562005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003679933,"about_ca_topic_score_gemma":0.0007938342,"domain_scores_codex":[0.9998938,0.00001668878,0.00001102167,0.00002429199,0.00003355042,0.00002075008],"domain_scores_gemma":[0.999844,0.00002169275,0.00003401979,0.00003720158,0.00001522934,0.00004791834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005211466,0.00001058452,0.0001812871,0.00001047689,0.000001946934,0.00004143607,0.00001333789,0.00003618501,0.9988508,0.00008143717,0.000009762683,0.0007105288],"study_design_scores_gemma":[0.00001776127,0.0004637415,0.006094116,0.00001046625,0.00001591632,0.0003883126,0.00007486188,0.001309948,0.9895672,0.00005190147,0.002003125,0.000002615621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959914,0.0004089162,0.001970681,0.0000335812,0.00001477795,0.00001607537,0.00009743202,0.00004086616,0.001426498],"genre_scores_gemma":[0.9954818,0.0002545241,0.001767681,0.00001621444,0.00000499455,0.00001319354,0.0001628318,0.00001500939,0.00228369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001016269,"threshold_uncertainty_score":0.00339973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02479853143400912,"score_gpt":0.2217934021406104,"score_spread":0.1969948707066013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}