{"id":"W2121093397","doi":"10.1677/jme.0.0240001","title":"Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications","year":2000,"lang":"en","type":"review","venue":"Journal of Molecular Endocrinology","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Subtilisin; Proteases; Proteolysis; Proprotein Convertases; Proteolytic enzymes; Biochemistry; Chemistry; Enzyme; Protease; Biology; Computational biology; Cell biology; LDL receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001263221,0.0006758478,0.001544376,0.0003293773,0.0001063103,0.00006705747,0.0009793737,0.0005206112,0.0003357915],"category_scores_gemma":[0.00006309929,0.0005790359,0.001256821,0.0002913187,0.0001332601,0.000007643852,0.0002462494,0.0006163337,0.0001601532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007947849,"about_ca_system_score_gemma":0.0005643952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002656282,"about_ca_topic_score_gemma":0.000004997679,"domain_scores_codex":[0.9964254,0.0005498413,0.001275292,0.000761317,0.0003803406,0.0006077792],"domain_scores_gemma":[0.9973083,0.00003755211,0.0009154367,0.001086777,0.0002579491,0.0003939483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004686871,0.0009094065,0.00001067687,0.001681795,0.003508751,0.001844139,0.00002447805,0.000197037,0.1256242,0.000544375,0.009902456,0.855284],"study_design_scores_gemma":[0.0004806136,0.0007363638,0.000001854403,0.0005282831,0.001133903,0.0006016191,0.00001135793,6.039756e-7,0.02373638,0.000397662,0.9718093,0.0005620612],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002530707,0.9861052,0.00836214,0.0001027057,0.0003587859,0.001788598,0.0002609027,0.00002057427,0.0004704021],"genre_scores_gemma":[0.004391638,0.9911029,0.001022186,0.001309027,0.0007288157,0.0006191815,0.0003354861,0.0001637198,0.0003270555],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9619069,"threshold_uncertainty_score":0.9996661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02371109204130991,"score_gpt":0.3165096879385956,"score_spread":0.2927985958972857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}