{"id":"W2121130537","doi":"10.1093/molehr/gav007","title":"Genome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity","year":2015,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; DNA methylation; Methylation; Gene; Trophoblast; CpG site; Cell biology; Molecular biology; Differentially methylated regions; Gene expression; Placenta; Genetics; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001201765,0.0003116062,0.0005442551,0.0001908202,0.0003104552,0.00005176215,0.00007918495,0.0001500763,0.00002606285],"category_scores_gemma":[0.0003619189,0.0003016799,0.000164747,0.0002523007,0.0001937026,0.0002798892,0.00007099661,0.0003077818,0.00001455273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001576519,"about_ca_system_score_gemma":0.00005141844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001353342,"about_ca_topic_score_gemma":0.00004022763,"domain_scores_codex":[0.9974926,0.0003457812,0.0004700363,0.0009928227,0.0004033123,0.0002954939],"domain_scores_gemma":[0.9985039,0.00003446149,0.0001707779,0.0008615332,0.0002436198,0.0001857318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004934831,0.0001876965,0.002179479,0.000252759,0.000349151,0.00007954488,0.0006509511,0.0003125577,0.9920045,0.00003167032,0.000007174935,0.003451024],"study_design_scores_gemma":[0.004011751,0.0005896155,0.09919599,0.000141541,0.0007450632,0.0001760397,0.0001804985,0.0002868051,0.890108,0.003758104,0.0003560313,0.0004505142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712378,0.008715059,0.01729975,0.00063754,0.0002416742,0.001530584,0.000005988708,0.0001881875,0.0001433633],"genre_scores_gemma":[0.9988937,0.0001604761,0.0002848209,0.00003988884,0.0001264685,0.0001569816,0.00004531649,0.0000412844,0.0002510626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1018965,"threshold_uncertainty_score":0.9999436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02315442274479894,"score_gpt":0.2722888275211032,"score_spread":0.2491344047763042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}