{"id":"W2121136691","doi":"10.1016/j.bmcl.2013.03.044","title":"Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1","year":2013,"lang":"fi","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Program for New Century Excellent Talents in University; National Natural Science Foundation of China","keywords":"Chaetomium globosum; Chemistry; Ginkgo biloba; Cytotoxic T cell; Cytotoxicity; Stereochemistry; Fungus; Two-dimensional nuclear magnetic resonance spectroscopy; IC50; Biochemistry; In vitro; Botany; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005835717,0.0002845358,0.0002072229,0.0002779037,0.0002017478,0.0002771055,0.0002341014,0.0002292482,0.001498713],"category_scores_gemma":[0.0001166767,0.00009595608,0.0001465057,0.0002801896,0.0001392654,0.0001764128,0.0002285622,0.000462718,0.0005011556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001924938,"about_ca_system_score_gemma":0.0001814304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029105,"about_ca_topic_score_gemma":0.001273183,"domain_scores_codex":[0.9999571,0.000006899439,0.000003974427,0.000007383926,0.00001249177,0.00001217617],"domain_scores_gemma":[0.999933,0.00002195237,0.00001112452,0.00001074538,0.0000087348,0.00001452314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001224913,0.000009199364,0.0001027058,0.00004269101,0.000003220663,0.0001201385,0.00002326238,0.0001583206,0.9973013,0.00006358782,0.00004319412,0.002009972],"study_design_scores_gemma":[0.00002361643,0.0003019039,0.003903982,0.000008947898,0.00001936547,0.0003941804,0.00004473489,0.0003886075,0.9912139,0.00009714942,0.003594323,0.000009420109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917701,0.001547239,0.001253868,0.00008222265,0.00002145346,0.00003210601,0.001083961,0.00006758281,0.004141451],"genre_scores_gemma":[0.9913707,0.0009840699,0.0008116974,0.00002849157,0.000009536539,0.00001729661,0.002180179,0.00002627206,0.004571726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001498713,"threshold_uncertainty_score":0.005013645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00916609497632609,"score_gpt":0.20591089598544,"score_spread":0.1967448010091139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}