{"id":"W2121136691","doi":"10.1016/j.bmcl.2013.03.044","title":"Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1","year":2013,"lang":"fi","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Program for New Century Excellent Talents in University; National Natural Science Foundation of China","keywords":"Chaetomium globosum; Chemistry; Ginkgo biloba; Cytotoxic T cell; Cytotoxicity; Stereochemistry; Fungus; Two-dimensional nuclear magnetic resonance spectroscopy; IC50; Biochemistry; In vitro; Botany; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004439068,0.001180771,0.001465927,0.0001190062,0.0002912591,0.0001511049,0.0009878253,0.0008848527,0.03606024],"category_scores_gemma":[0.0006929946,0.0009728546,0.0004235382,0.0008555333,0.0009529156,0.000263354,0.000348265,0.001639102,0.004172604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006777489,"about_ca_system_score_gemma":0.0003184568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002373212,"about_ca_topic_score_gemma":0.000008551587,"domain_scores_codex":[0.9940759,0.0001170529,0.001270703,0.001758255,0.001185931,0.001592149],"domain_scores_gemma":[0.9962812,0.0002177461,0.0005432653,0.001558929,0.000282045,0.001116838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001782314,0.0002438744,0.0007326038,0.0005759836,0.0005387631,0.0002710175,0.0002599204,9.231493e-8,0.8724948,0.000002039128,0.1208702,0.003832589],"study_design_scores_gemma":[0.002549117,0.0001218245,0.007786078,0.001244692,0.0009962077,0.0002706087,0.0005138093,0.00002877656,0.9519799,0.0000292299,0.0334033,0.001076497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8462284,0.008242547,0.00002558856,0.1412627,0.001695267,0.0009201016,0.0002204909,0.0002080293,0.001196842],"genre_scores_gemma":[0.9633606,0.0009593159,0.0003034834,0.01675246,0.0133503,0.000009850511,0.0004711028,0.0001670219,0.004625832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1245103,"threshold_uncertainty_score":0.9992722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00916609497632609,"score_gpt":0.20591089598544,"score_spread":0.1967448010091139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}