{"id":"W2121150535","doi":"10.1016/j.bbi.2014.02.016","title":"HIV-1 Nef expression in microglia disrupts dopaminergic and immune functions with associated mania-like behaviors","year":2014,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Microglia; Dopaminergic; Striatum; Dopamine transporter; Dopamine; Genetically modified mouse; Transgene; Endocrinology; Chemistry; Biology; Internal medicine; Inflammation; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451252,0.0002961459,0.0002029868,0.0003082793,0.0003283851,0.000317609,0.0002377595,0.0004238226,0.001739674],"category_scores_gemma":[0.0001675195,0.000198564,0.0002857399,0.0001118797,0.0003888836,0.0001497621,0.00017111,0.0008097786,0.0001952954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005092148,"about_ca_system_score_gemma":0.0002872148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00195597,"about_ca_topic_score_gemma":0.004082645,"domain_scores_codex":[0.9997782,0.0000432805,0.00001146335,0.00002474931,0.00003555441,0.0001068534],"domain_scores_gemma":[0.9998862,0.00001849338,0.00002806712,0.00001640326,0.00001017398,0.00004078192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006615866,0.0002170011,0.000354787,0.00001976949,0.00001118712,0.000154332,0.0000300399,0.00008540026,0.9968396,0.0002419294,0.00007945845,0.001304953],"study_design_scores_gemma":[0.0001167772,0.001779567,0.02489893,0.00001856005,0.00004008287,0.001132141,0.0002453758,0.002153347,0.9675799,0.0003640783,0.001653992,0.00001721257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997888,0.0002974742,0.0004263264,0.0001147285,0.00003730464,0.00001734472,0.0001454171,0.00002319082,0.001050113],"genre_scores_gemma":[0.9971799,0.0002474119,0.0005946746,0.00005200923,0.00001173311,0.00002524378,0.0000904941,0.000007113834,0.001791455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00195597,"threshold_uncertainty_score":0.005819798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009581831542418798,"score_gpt":0.2451895406174645,"score_spread":0.2356077090750457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}