{"id":"W2121157346","doi":"10.1534/genetics.113.158949","title":"The Anaphase Promoting Complex Regulates Yeast Lifespan and rDNA Stability by Targeting Fob1 for Degradation","year":2013,"lang":"en","type":"article","venue":"Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Biology; Genetics; Cell biology; Genome instability; Mutant; Yeast; Mutation; Longevity; Ribosome biogenesis; Cell cycle; Proteasome; Cell; Gene; DNA damage; DNA; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001076851,0.0002912784,0.0001349588,0.0002770934,0.0001598078,0.0003118318,0.000179486,0.000222798,0.00106064],"category_scores_gemma":[0.0001363332,0.0001260898,0.0001323256,0.0001134927,0.0001529939,0.000194029,0.0002291291,0.0002236538,0.0004752201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003521604,"about_ca_system_score_gemma":0.0001762052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007936977,"about_ca_topic_score_gemma":0.0008896798,"domain_scores_codex":[0.9999313,0.000006372631,0.000006356643,0.0000245176,0.00001768946,0.00001381528],"domain_scores_gemma":[0.9998951,0.000008719237,0.00004802895,0.000008594323,0.00001350995,0.0000260687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005582978,0.000007675201,0.0005019877,0.00002604763,0.000002611604,0.00002887368,0.000009300351,0.00004409812,0.9971064,0.0001079185,0.0000498394,0.002059369],"study_design_scores_gemma":[0.00002211045,0.00009834381,0.02561112,0.00001340363,0.00001716749,0.000384059,0.00003300895,0.00214974,0.9664397,0.0001824457,0.005040361,0.00000847824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885936,0.0056133,0.003266021,0.00008803781,0.00001849148,0.0000123982,0.0003308493,0.0001989002,0.001878391],"genre_scores_gemma":[0.9941438,0.001349981,0.00206823,0.00002914435,0.000007053834,0.00001049782,0.000330066,0.00003380436,0.002027338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00106064,"threshold_uncertainty_score":0.003548205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01608123601067918,"score_gpt":0.2356408817853948,"score_spread":0.2195596457747156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}