{"id":"W2121201545","doi":"10.1373/clinchem.2014.225854","title":"Integrative Bioinformatics Analysis Reveals New Prognostic Biomarkers of Clear Cell Renal Cell Carcinoma","year":2014,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada; Prostate Cancer Canada","keywords":"Gene knockdown; Clear cell renal cell carcinoma; Biology; Hazard ratio; Gene silencing; Proportional hazards model; Cancer; Renal cell carcinoma; Cancer research; Internal medicine; Oncology; Disease; Small interfering RNA; Aryl hydrocarbon receptor; microRNA; Cell growth; Gene; Medicine; RNA; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001061979,0.0006393053,0.0009263809,0.003058751,0.0004675446,0.001156527,0.0004849811,0.0002629867,0.001163875],"category_scores_gemma":[0.001581694,0.0001395243,0.001411766,0.00271756,0.0002230022,0.0003713345,0.000765626,0.0003684526,0.00048823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004983167,"about_ca_system_score_gemma":0.001206052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001517755,"about_ca_topic_score_gemma":0.002899668,"domain_scores_codex":[0.9992602,0.000164416,0.00006225517,0.0002474117,0.0001733385,0.00009226806],"domain_scores_gemma":[0.9991356,0.0003600053,0.0001902942,0.00006002292,0.0001531564,0.0001009582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001758814,0.0004206994,0.7248231,0.001925664,0.002208443,0.001614785,0.0004022451,0.01783131,0.1104509,0.002058418,0.007808974,0.1286966],"study_design_scores_gemma":[0.0001158742,0.0009132928,0.7836724,0.0001949135,0.00257471,0.002604677,0.0006566089,0.1586924,0.0217977,0.008723973,0.01992668,0.0001267489],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9329936,0.006399602,0.0297839,0.0009886591,0.00005813482,0.0001288353,0.02562692,0.001226222,0.00279406],"genre_scores_gemma":[0.9410902,0.001768342,0.0246662,0.0001977758,0.00004749509,0.0001176186,0.03151412,0.00008680847,0.0005114196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003058751,"threshold_uncertainty_score":0.005616307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02893993624048449,"score_gpt":0.3046526215501741,"score_spread":0.2757126853096897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}