{"id":"W2121220704","doi":"10.1073/pnas.0710091104","title":"Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance; Canada Research Chairs; U.S. Department of Defense; McGill University; Breast Cancer Alliance","keywords":"Focal adhesion; Tumor progression; Cancer research; Mammary tumor; Biology; Mammary gland; Genetically modified mouse; Cell biology; Kinase; Signal transduction; Cell adhesion molecule; Pathology; Breast cancer; Cancer; Transgene; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002976456,0.0001284952,0.0002211612,0.000300945,0.0002202091,0.00001871016,0.001047021,0.000116536,0.00002256934],"category_scores_gemma":[0.0007580375,0.00006827807,0.000177967,0.001377871,0.001104194,0.000298503,0.0005104811,0.0003673944,0.00000182274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008193808,"about_ca_system_score_gemma":0.0001066144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003163572,"about_ca_topic_score_gemma":5.139919e-8,"domain_scores_codex":[0.9958507,0.00001728258,0.000553213,0.0003238746,0.002995411,0.0002595409],"domain_scores_gemma":[0.9985673,0.0001820351,0.0005492938,0.0000355656,0.0005761846,0.00008962527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001607141,0.0001773223,0.009822135,0.0001614343,0.000008424373,2.006159e-7,0.0000909614,0.00000335133,0.9716418,0.008774525,0.000805962,0.008353127],"study_design_scores_gemma":[0.0003495032,0.0001556912,0.2116794,0.0004096557,0.00001049513,0.00004256728,0.00009494508,0.0004440126,0.7802057,0.005850251,0.0006962311,0.00006150788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877053,0.0004642346,0.00002116922,0.006418839,0.00004048959,0.0006148246,0.000006462929,0.00001582057,0.004712877],"genre_scores_gemma":[0.9958443,0.0001024361,0.003330861,0.0002039986,0.0001034086,0.00000927608,2.875702e-7,0.000007263788,0.0003981575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2018573,"threshold_uncertainty_score":0.4068449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04150465187186323,"score_gpt":0.3466696962437091,"score_spread":0.3051650443718458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}