{"id":"W2121270713","doi":"10.1373/clinchem.2012.184903","title":"Is Early Detection of Cancer with Circulating Biomarkers Feasible?","year":2012,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Global Cancer Incidence and Screening","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Asymptomatic; Breast cancer; Biomarker; Cancer; Stage (stratigraphy); Internal medicine; Population; Oncology; Ovarian cancer; Cancer screening; Disease; Cancer staging; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01075399,0.0005836683,0.001731323,0.0009343966,0.0005306929,0.003567077,0.00142419,0.005789815,0.0076443],"category_scores_gemma":[0.06115575,0.0004505341,0.0007455958,0.001372807,0.003178375,0.004618406,0.000903861,0.002964695,0.002659598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001001809,"about_ca_system_score_gemma":0.002244695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121067,"about_ca_topic_score_gemma":0.0007661427,"domain_scores_codex":[0.9944377,0.002620665,0.000452687,0.0008293937,0.001289467,0.000370147],"domain_scores_gemma":[0.9565771,0.02960939,0.006549394,0.001506144,0.004453118,0.001304907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.003469995,0.0008226879,0.1405578,0.007678845,0.0006816844,0.001788216,0.0003982803,0.0006476776,0.004306464,0.0292501,0.08252653,0.7278718],"study_design_scores_gemma":[0.001339456,0.006786517,0.1548246,0.01863074,0.002374975,0.01114311,0.004225948,0.003315743,0.01260048,0.1984547,0.5858591,0.0004445675],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.04652324,0.4126046,0.01701638,0.4882601,0.01133778,0.000174667,0.0009948884,0.0002119057,0.02287648],"genre_scores_gemma":[0.5522153,0.2955769,0.01504595,0.09997994,0.03174828,0.0004278739,0.000969663,0.00007610576,0.00395996],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01075399,"threshold_uncertainty_score":0.0568732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1562489916514909,"score_gpt":0.436991011890282,"score_spread":0.2807420202387911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}