{"id":"W2121300131","doi":"10.7554/elife.08440","title":"Network structure of brain atrophy in de novo Parkinson's disease","year":2015,"lang":"en","type":"article","venue":"eLife","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":259,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael J. Fox Foundation for Parkinson's Research; W. Garfield Weston Foundation; National Institute of Mental Health; Alzheimer's Association","keywords":"Atrophy; Substantia nigra; Basal ganglia; Neuroscience; Parkinson's disease; Magnetic resonance imaging; Pathology; Dopaminergic; Voxel-based morphometry; Neuromelanin; Temporal lobe; Medicine; Biology; Disease; Central nervous system; Dopamine; White matter; Epilepsy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104467,0.0001379669,0.0002563323,0.00006702865,0.00001982195,0.000006517958,0.00007018194,0.00006149829,0.00007019294],"category_scores_gemma":[0.0001440704,0.0001165079,0.00007179411,0.0002053468,0.00002994145,0.00003974817,0.00003572025,0.00009663232,0.0000184552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001105445,"about_ca_system_score_gemma":0.0003276468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005053994,"about_ca_topic_score_gemma":0.00003070377,"domain_scores_codex":[0.9989579,0.00005431953,0.0001735438,0.0002123467,0.0003115835,0.0002902567],"domain_scores_gemma":[0.9990208,0.00002535992,0.00006305757,0.0002697592,0.00005868034,0.0005623933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001615526,0.0004161157,0.9797106,0.00007959838,0.0001039447,0.001250539,0.0002607393,0.0006903457,0.001039951,0.0009053063,0.01151302,0.002414318],"study_design_scores_gemma":[0.006443743,0.0002985719,0.8927534,0.0001689735,0.0001635059,0.00002476797,0.00006446614,0.0005187794,0.001178832,0.004342368,0.09384795,0.000194692],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966246,0.00167756,0.0001464719,0.0007129161,0.0001482085,0.0002339546,0.00006336073,0.00003076508,0.0003621719],"genre_scores_gemma":[0.9957142,0.00002197884,0.00210108,0.001626434,0.0002921222,0.000009854974,0.00005039044,0.00002201454,0.0001619214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08695725,"threshold_uncertainty_score":0.4751054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899026315236821,"score_gpt":0.2691048571808162,"score_spread":0.250114594028448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}