{"id":"W2121302081","doi":"10.1158/1078-0432.ccr-07-1934","title":"Interactions between Bortezomib and Romidepsin and Belinostat in Chronic Lymphocytic Leukemia Cells","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Romidepsin; Bortezomib; Cancer research; Histone deacetylase; Vorinostat; Apoptosis; Chronic lymphocytic leukemia; Transfection; Proteasome inhibitor; Chemistry; Biology; Molecular biology; Cell culture; Leukemia; Histone; Immunology; Biochemistry; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001465616,0.0002934139,0.0004871947,0.0001643806,0.0002622241,0.0004626494,0.0001650285,0.0002628927,0.001529351],"category_scores_gemma":[0.0001279307,0.0001596726,0.0003386154,0.0002096085,0.000157735,0.0002289599,0.0002107454,0.000314674,0.0006722003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006257166,"about_ca_system_score_gemma":0.0002907002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001190158,"about_ca_topic_score_gemma":0.00203028,"domain_scores_codex":[0.999635,0.00008899954,0.00002312245,0.00005808435,0.0001245958,0.00007017785],"domain_scores_gemma":[0.999917,0.00001681408,0.00002385054,0.00000745316,0.00001481243,0.00002003957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005751189,0.00008751008,0.001739888,0.0001357901,0.00004907082,0.000140857,0.00004026667,0.0001603945,0.9930559,0.00005780908,0.0002007189,0.00375669],"study_design_scores_gemma":[0.0001738527,0.001975432,0.04804432,0.00002420733,0.0001087179,0.001439347,0.0002092188,0.00175119,0.9325166,0.00008120392,0.01365908,0.0000168002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880288,0.008387594,0.0008119946,0.0001774802,0.00004954588,0.00003185509,0.0003373289,0.00004621929,0.002129172],"genre_scores_gemma":[0.9953659,0.001856747,0.0006050051,0.00010628,0.00001928706,0.00003536881,0.0005954708,0.000005220752,0.001410758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529351,"threshold_uncertainty_score":0.005116224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1622679616721908,"score_gpt":0.4939002752768028,"score_spread":0.331632313604612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}