{"id":"W2121327910","doi":"10.1074/jbc.m403763200","title":"Nucleic Acid Is a Novel Ligand for Innate, Immune Pattern Recognition Collectins Surfactant Proteins A and D and Mannose-binding Lectin","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Medical Research Council; Canadian Institutes of Health Research; University of California, San Francisco; Wellcome Trust","keywords":"Collectin; Mannan-binding lectin; Lectin; Nucleic acid; Innate immune system; Mannose; Ficolin; Surfactant protein D; Mannose receptor; Ligand (biochemistry); C-type lectin; Chemistry; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000412453,0.0001490971,0.0003078414,0.00005028097,0.0001909435,0.00003148057,0.00009925025,0.0003478107,0.00004257981],"category_scores_gemma":[0.0002893809,0.0001091264,0.00009101904,0.00008467657,0.0001459158,0.00009577342,0.00006037926,0.0003253599,0.000004962928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005711638,"about_ca_system_score_gemma":0.00006067835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008223099,"about_ca_topic_score_gemma":7.239183e-7,"domain_scores_codex":[0.9991056,0.00003254081,0.0004541572,0.0001653448,0.00002923515,0.0002131145],"domain_scores_gemma":[0.999267,0.0001043339,0.0003851372,0.00008401063,0.0001317208,0.00002777535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008035534,0.0001028,0.0003794944,0.00005364857,0.0001066587,0.000006205528,0.0002374219,1.258996e-7,0.9928296,0.000001234323,0.00003305224,0.005446157],"study_design_scores_gemma":[0.00318141,0.0006436685,0.001928047,0.0001669773,0.00003270018,0.001297413,0.000239025,0.000001941017,0.9908724,0.0002312917,0.001256784,0.0001483857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965127,0.001961928,0.0004508158,0.0006666019,0.00009947558,0.00021211,0.00003106337,0.00001326055,0.00005203823],"genre_scores_gemma":[0.9986042,0.0005664297,0.0005249244,0.00007006696,0.00004540376,0.00001096471,0.0000330432,0.000008702135,0.000136316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005297771,"threshold_uncertainty_score":0.4450046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02580781301940269,"score_gpt":0.239488007330165,"score_spread":0.2136801943107623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}