{"id":"W2121352895","doi":"10.1091/mbc.e02-04-0235","title":"Extracellular Signal-regulated Kinase Mediates Phosphorylation of Tropomyosin-1 to Promote Cytoskeleton Remodeling in Response to Oxidative Stress: Impact on Membrane Blebbing","year":2003,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval; Hôtel-Dieu de Québec","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Cell biology; MAPK/ERK pathway; Biology; Kinase; Tropomyosin; Paxillin; Focal adhesion; Phosphorylation; Protein kinase A; Mitogen-activated protein kinase kinase; Actin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046078,0.0004094419,0.0001817128,0.00009827992,0.0001095238,0.0001478144,0.0001241168,0.0002445446,0.001174608],"category_scores_gemma":[0.00007102462,0.0000959,0.0002103491,0.00007520968,0.0001126591,0.0001752202,0.000133052,0.0003616335,0.0002052841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002601691,"about_ca_system_score_gemma":0.00009933538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003006379,"about_ca_topic_score_gemma":0.0005036389,"domain_scores_codex":[0.999941,0.000009364785,0.000003409011,0.00001304969,0.00001067873,0.00002244664],"domain_scores_gemma":[0.999954,0.000004491498,0.00001380791,0.000003100028,0.000005382934,0.00001927122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001078992,0.00001146096,0.00006190551,0.00002346654,0.000002637378,0.0000286928,0.0000046503,0.00001842461,0.9993937,0.00002222971,0.00001504337,0.0003098811],"study_design_scores_gemma":[0.00003131041,0.0002512061,0.01317946,0.000007489852,0.00001218168,0.0003596766,0.00001678214,0.0009161014,0.9836559,0.00004878327,0.001516252,0.000004810371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946795,0.002854619,0.001068812,0.0001289663,0.00002648882,0.00003863614,0.0003529324,0.00002530726,0.0008248168],"genre_scores_gemma":[0.9949343,0.001558229,0.00121814,0.00005969977,0.00001106958,0.00004262475,0.0004739036,0.000006527535,0.001695537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001174608,"threshold_uncertainty_score":0.003929436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00668539694403016,"score_gpt":0.2532647630699282,"score_spread":0.2465793661258981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}