{"id":"W2121378565","doi":"10.2478/s11535-006-0014-6","title":"Targeting of solid tumors and blood malignancies by antibody-based therapies — EGFR-pathway as an example","year":2006,"lang":"en","type":"article","venue":"Open Life Sciences","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation; Manitoba Medical Service Foundation","keywords":"ERBB3; ErbB; Epidermal growth factor receptor; Cancer research; Receptor tyrosine kinase; MAPK/ERK pathway; Epidermal growth factor; PI3K/AKT/mTOR pathway; Tyrosine kinase; Protein kinase B; Signal transduction; Biology; ERBB4; Receptor; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001481358,0.0002938821,0.0002651507,0.0003190989,0.0001128602,0.0003129895,0.0001944429,0.0004996896,0.001342853],"category_scores_gemma":[0.00007512847,0.00005047894,0.0001897851,0.0002041089,0.0001166535,0.000243308,0.000172477,0.0004667559,0.0004309654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001932204,"about_ca_system_score_gemma":0.00009336238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002287574,"about_ca_topic_score_gemma":0.0004998115,"domain_scores_codex":[0.9999536,0.0000125333,0.000002804532,0.000005284166,0.00001533649,0.00001035616],"domain_scores_gemma":[0.9999794,0.000006014351,0.000002068175,0.00000150839,0.000005399751,0.000005681623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009696131,0.001613869,0.001153238,0.002438259,0.0001008732,0.003339855,0.0001078951,0.002380183,0.4727653,0.02274076,0.01733874,0.4750514],"study_design_scores_gemma":[0.0005899037,0.005420524,0.006132978,0.0002939241,0.000265415,0.01478248,0.00007856857,0.005147484,0.4281051,0.007191797,0.5319529,0.0000389628],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2286349,0.6659095,0.02321268,0.005697655,0.001788246,0.0003785954,0.0003178637,0.0003493314,0.07371126],"genre_scores_gemma":[0.5956519,0.352002,0.01695135,0.001891075,0.0005859662,0.0001687478,0.0003447994,0.00003145613,0.03237279],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001342853,"threshold_uncertainty_score":0.004492342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06080071927829519,"score_gpt":0.3812281827530076,"score_spread":0.3204274634747125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}