{"id":"W2121382767","doi":"10.1016/j.molmed.2007.05.003","title":"Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health","year":2007,"lang":"en","type":"article","venue":"Trends in Molecular Medicine","topic":"Birth, Development, and Health","field":"Medicine","cited_by":662,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Offspring; Adrenal function; Hypothalamic–pituitary–adrenal axis; Epigenetics; Endocrinology; Malnutrition; Pregnancy; Medicine; Low birth weight; Internal medicine; Physiology; Psychology; Developmental psychology; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001268244,0.0001671991,0.000573458,0.0006258463,0.00003137581,0.000001164184,0.00005764785,0.00009767621,0.00008490481],"category_scores_gemma":[0.00003803524,0.0001411823,0.00004460642,0.0005303545,0.0001731442,0.00002212655,0.00002990587,0.0002197071,5.315578e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008133834,"about_ca_system_score_gemma":0.000128461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003881446,"about_ca_topic_score_gemma":0.0002089998,"domain_scores_codex":[0.9981875,0.00003883338,0.0006976819,0.000272216,0.0004319307,0.0003717706],"domain_scores_gemma":[0.9992641,0.00002328438,0.0002209969,0.0002130739,0.000069243,0.0002093171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0005602274,0.0004351293,0.03324953,0.001855958,0.0001350652,0.0002505177,0.002283389,0.000003988438,0.1304449,0.06488635,0.0000608153,0.7658342],"study_design_scores_gemma":[0.006501729,0.005274429,0.9476303,0.001079677,0.00009995719,0.0002172898,0.0009202003,0.00008619016,0.028684,0.009177503,0.0001399695,0.000188754],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9071211,0.006022112,0.08125249,0.002975377,0.0002481615,0.0004532187,0.000003676024,0.00003898635,0.001884899],"genre_scores_gemma":[0.9826257,0.001214504,0.01538511,0.0006272762,0.0000479647,0.000006108882,0.00004501343,0.00002242964,0.00002585916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9143808,"threshold_uncertainty_score":0.5757247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02704349110581067,"score_gpt":0.3205026157533759,"score_spread":0.2934591246475652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}