{"id":"W2121383084","doi":"10.1161/01.res.88.2.223","title":"Functional Alterations of the <i>Nppa</i> Promoter Are Linked to Cardiac Ventricular Hypertrophy in WKY/WKHA Rat Crosses","year":2001,"lang":"en","type":"article","venue":"Circulation Research","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Quantitative trait locus; Internal medicine; Left ventricular hypertrophy; Ventricle; Biology; Endocrinology; Locus (genetics); Single-nucleotide polymorphism; Muscle hypertrophy; Atrial natriuretic peptide; Genetics; Gene; Blood pressure; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005305095,0.00008814309,0.0001125968,0.0001437085,0.0001943974,0.00004765794,0.0001344026,0.00010664,0.00005706562],"category_scores_gemma":[0.0002681787,0.00007331556,0.0001029194,0.0006581346,0.00008361781,0.000009330507,0.0001008799,0.0001432457,0.00001674067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004468143,"about_ca_system_score_gemma":0.0001258949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003500852,"about_ca_topic_score_gemma":0.00003200985,"domain_scores_codex":[0.9985625,0.0002672982,0.0002350252,0.0002771498,0.0004284357,0.0002296566],"domain_scores_gemma":[0.9990808,0.00002481942,0.00005635298,0.0003574156,0.0004107923,0.00006981284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006560023,0.00008726622,0.09325027,0.00002158749,0.00001763618,0.000005896447,0.00004893078,0.02823157,0.8762463,0.0001619592,0.00101932,0.000843592],"study_design_scores_gemma":[0.0008452234,0.00009220628,0.7303719,0.0001070308,0.00001035656,0.00001686818,0.00009749387,0.002249883,0.2345385,0.0003909793,0.03104533,0.0002342474],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954255,0.0004969401,0.001942598,0.001086409,0.0001298205,0.0006624862,0.0000108648,0.000006253706,0.0002390905],"genre_scores_gemma":[0.9989492,0.00001909405,0.00008393409,0.0001180549,0.0002362188,0.0001003208,0.00007708033,0.00001308157,0.0004029842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6417078,"threshold_uncertainty_score":0.2989722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04696508356146688,"score_gpt":0.3136526734705455,"score_spread":0.2666875899090786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}