{"id":"W2121389760","doi":"10.1016/j.celrep.2015.08.084","title":"Reversion of FMR1 Methylation and Silencing by Editing the Triplet Repeats in Fragile X iPSC-Derived Neurons","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Yonsei University College of Medicine; Azrieli Foundation; National Research Foundation of Korea; Yonsei University; National Research Foundation; Rosetrees Trust","keywords":"FMR1; Fragile X syndrome; Biology; Trinucleotide repeat expansion; Gene silencing; Chromatin; Induced pluripotent stem cell; Genetics; DNA methylation; CpG site; CRISPR; Embryonic stem cell; Cell biology; Gene; Fragile x; Gene expression; Allele","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002737915,0.00007730715,0.00008347908,0.00002208615,0.00003638253,0.000007787594,0.00004464578,0.00005589077,0.000002805502],"category_scores_gemma":[0.0001479246,0.00006563149,0.00002289196,0.00006073668,0.00003560389,0.000003021213,0.00008675725,0.00005592445,2.832411e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006491995,"about_ca_system_score_gemma":0.00004127375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004072285,"about_ca_topic_score_gemma":0.00001199074,"domain_scores_codex":[0.9992747,0.00004732922,0.0002316259,0.0002309475,0.0001079455,0.0001074537],"domain_scores_gemma":[0.9995658,0.00001012889,0.0001570901,0.0001831044,0.0000391917,0.00004461584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009054729,0.00001896345,0.005550211,0.000009446146,0.000002390288,0.000009567703,0.0001938775,0.00009464621,0.9896715,2.280868e-7,0.003762928,0.0006771995],"study_design_scores_gemma":[0.0002793516,0.00009868462,0.01308648,0.00001145545,0.00000738071,0.00002354192,0.0005334234,0.00008303448,0.9790677,0.00005693659,0.006656768,0.00009522169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997247,0.0008877381,0.00007691567,0.0000911271,0.0001515415,0.0001302156,0.00000192847,0.000003024243,0.001410488],"genre_scores_gemma":[0.999271,0.0001880804,0.0001489456,0.00008804958,0.00001402583,0.00000492296,0.00004543884,0.000009891784,0.0002295937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01060377,"threshold_uncertainty_score":0.2676374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184021246254152,"score_gpt":0.2200650456968383,"score_spread":0.2082248332342968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}