{"id":"W2121433760","doi":"10.4049/jimmunol.177.12.8595","title":"Molecular Basis of TCR Selectivity, Cross-Reactivity, and Allelic Discrimination by a Bacterial Superantigen: Integrative Functional and Energetic Mapping of the SpeC-Vβ2.1 Molecular Interface","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Lawson Health Research Institute; Western University","funders":"National Institute of Allergy and Infectious Diseases","keywords":"T-cell receptor; Mutant; Spec#; Biology; Chemistry; T cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008301935,0.000214388,0.00009549018,0.00006803327,0.00006146792,0.0001652401,0.000159429,0.0001229273,0.0005027355],"category_scores_gemma":[0.0000854566,0.00008817124,0.00009780285,0.00005975495,0.0001262788,0.000101589,0.0001351944,0.0002219696,0.0001086549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001470419,"about_ca_system_score_gemma":0.00008453539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002211018,"about_ca_topic_score_gemma":0.0002144152,"domain_scores_codex":[0.9999422,0.000007857497,0.000002938485,0.00001229092,0.00001898155,0.00001574562],"domain_scores_gemma":[0.9999638,0.000007077261,0.00001142935,0.000003399115,0.000004660943,0.000009712182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003565103,0.000005472281,0.0002873417,0.000004125038,0.000001672619,0.00001253539,0.000003935339,0.0001133543,0.9990175,0.00005564262,0.000003736779,0.000459116],"study_design_scores_gemma":[0.00001223199,0.0001588491,0.01504042,0.000003811709,0.00001319039,0.0003703543,0.00002789643,0.006157092,0.9775575,0.0001493369,0.0005044866,0.000004807623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982827,0.0001400837,0.001254244,0.00001009663,0.000001513449,0.000003240928,0.0000287646,0.000008475912,0.000271001],"genre_scores_gemma":[0.9992373,0.00007075577,0.0004845352,0.00001036922,0.000001038896,0.000003296918,0.00005362525,0.000004851218,0.0001341999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005027355,"threshold_uncertainty_score":0.001681805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007049119204961001,"score_gpt":0.2135586225970069,"score_spread":0.2065095033920459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}