{"id":"W2121478302","doi":"10.1128/jvi.77.24.13348-13360.2003","title":"Multispecific Vaccine-Induced Mucosal Cytotoxic TLymphocytes Reduce Acute-Phase Viral Replication but Fail inLong-Term Control of Simian Immunodeficiency VirusSIVmac239","year":2003,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Takeda Oncology; National Institutes of Health; Deutsche Forschungsgemeinschaft","keywords":"Virology; CTL*; Simian immunodeficiency virus; Biology; Modified vaccinia Ankara; Vaccination; Immunology; Cytotoxic T cell; HIV vaccine; Immunogen; Vaccinia; Neutralizing antibody; Virus; AIDS Vaccines; Antibody; Viral replication; Immune system; Vaccine trial; CD8; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001626449,0.0003831694,0.0002688376,0.000118427,0.0001290173,0.0002667183,0.0002535146,0.0002494817,0.001201815],"category_scores_gemma":[0.0001870084,0.0001308415,0.0002177893,0.00004275326,0.000150853,0.0001502473,0.000202047,0.0007471858,0.0003571229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002004813,"about_ca_system_score_gemma":0.0002225801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005720513,"about_ca_topic_score_gemma":0.001102315,"domain_scores_codex":[0.9998502,0.00001803744,0.00001047038,0.00002435105,0.00003134356,0.00006565487],"domain_scores_gemma":[0.9998385,0.0000279396,0.00002962212,0.00003017536,0.00002257389,0.00005119099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002579377,0.0001845021,0.0002960682,0.00003399186,0.000006477957,0.00003398884,0.00001781879,0.00007968232,0.9961119,0.00004430466,0.00005691609,0.002876386],"study_design_scores_gemma":[0.00008778447,0.004263696,0.008981251,0.00001585692,0.00003156892,0.0004091419,0.00006360235,0.001540738,0.9822625,0.00007331975,0.002265108,0.000005407412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980002,0.0007219832,0.0006476594,0.0000341401,0.00002096311,0.00002413403,0.00007693229,0.0000442609,0.000429869],"genre_scores_gemma":[0.9970796,0.0002176678,0.0005661355,0.00003871711,0.000007696272,0.00003468928,0.000250853,0.00001043814,0.001794175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001201815,"threshold_uncertainty_score":0.004020452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01961102865165617,"score_gpt":0.3161555883162591,"score_spread":0.296544559664603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}