{"id":"W2121478302","doi":"10.1128/jvi.77.24.13348-13360.2003","title":"Multispecific Vaccine-Induced Mucosal Cytotoxic TLymphocytes Reduce Acute-Phase Viral Replication but Fail inLong-Term Control of Simian Immunodeficiency VirusSIVmac239","year":2003,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Takeda Oncology; National Institutes of Health; Deutsche Forschungsgemeinschaft","keywords":"Virology; CTL*; Simian immunodeficiency virus; Biology; Modified vaccinia Ankara; Vaccination; Immunology; Cytotoxic T cell; HIV vaccine; Immunogen; Vaccinia; Neutralizing antibody; Virus; AIDS Vaccines; Antibody; Viral replication; Immune system; Vaccine trial; CD8; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007672263,0.0002976373,0.0008144214,0.0004288261,0.000200718,0.00001715254,0.000475167,0.0004077838,0.0004686113],"category_scores_gemma":[0.0004398372,0.0002318957,0.0003079905,0.0001980166,0.000265317,0.0002098845,0.00004758439,0.0006114256,0.0002778539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002132799,"about_ca_system_score_gemma":0.0004263945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003978289,"about_ca_topic_score_gemma":0.00001076346,"domain_scores_codex":[0.9969001,0.0008162335,0.001139364,0.000392569,0.0001253616,0.0006264116],"domain_scores_gemma":[0.9976377,0.0003186535,0.0009883498,0.0006619475,0.0002969437,0.00009637952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003331931,0.001239676,0.002399339,0.00001131009,0.0007985756,0.0002072156,0.000282806,0.00001155921,0.9836177,0.0003868307,0.0003289525,0.007384099],"study_design_scores_gemma":[0.02763689,0.006724753,0.01256367,0.00002854133,0.0002879937,0.002250455,0.0002501175,0.00002420833,0.9471924,0.0001442984,0.002654224,0.0002423958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916182,0.00598951,0.0007360959,0.0004025612,0.0005189746,0.0003965307,0.0001128818,0.00001964146,0.0002056144],"genre_scores_gemma":[0.9987286,0.0007104739,0.0001451717,0.0001062912,0.0000502307,0.00002440373,0.0000467693,0.00002639427,0.0001616526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03642525,"threshold_uncertainty_score":0.9456434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01961102865165617,"score_gpt":0.3161555883162591,"score_spread":0.296544559664603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}