{"id":"W2121487119","doi":"10.1161/strokeaha.109.551382","title":"A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Effects of a Targeted Exposure of Intravenous Repinotan in Patients With Acute Ischemic Stroke","year":2009,"lang":"en","type":"article","venue":"Stroke","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Tolerability; Placebo; Anesthesia; Randomized controlled trial; Clinical endpoint; Stroke (engine); Clinical trial; Pharmacodynamics; Population; Vital signs; Adverse effect; Internal medicine; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002444122,0.001830033,0.005005839,0.0005116413,0.0006108447,0.001071847,0.001095931,0.002699571,0.00804625],"category_scores_gemma":[0.004160787,0.0007839582,0.001724226,0.0004896239,0.001758179,0.001339784,0.0004185275,0.002605635,0.001189024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005647977,"about_ca_system_score_gemma":0.001331291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006035506,"about_ca_topic_score_gemma":0.0009120305,"domain_scores_codex":[0.9983255,0.0009318474,0.0001435301,0.0003366905,0.0001037355,0.0001586719],"domain_scores_gemma":[0.9980612,0.0006936316,0.0004829888,0.0001753948,0.0001605812,0.0004261885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9920345,0.002609338,0.0002092707,0.0002906761,0.000369961,0.00001919101,0.00002280624,0.00006765764,0.0006693955,0.00004707332,0.0002164115,0.003443918],"study_design_scores_gemma":[0.9759558,0.02308803,0.0004314518,0.00001106923,0.0001494411,0.00001110059,0.00000554727,0.0001193653,0.00006802101,0.0000384048,0.0001172687,0.000004505669],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775005,0.005112153,0.001179378,0.001114027,0.001439517,0.009946902,0.001052572,0.0002371714,0.002417812],"genre_scores_gemma":[0.975255,0.002065566,0.002710755,0.001852245,0.001093563,0.01388989,0.0009331212,0.00002599181,0.002173774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00804625,"threshold_uncertainty_score":0.02691734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00842898020487527,"score_gpt":0.2793701520081285,"score_spread":0.2709411718032532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}