{"id":"W2121487910","doi":"10.1128/jvi.03303-13","title":"Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints","year":2014,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; AIDS Vancouver","funders":"Medical Research Council; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"Biology; HLA-B; Virology; Epitope; CTL*; Virus; Human leukocyte antigen; HLA-B Antigens; Immune system; Immunology; Clade; Viral load; Gene; Antigen; Genetics; CD8; Phylogenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770401,0.0001674831,0.000191339,0.0001952779,0.0001545389,0.0003657274,0.000170637,0.0002444096,0.002599105],"category_scores_gemma":[0.0002891286,0.0001008854,0.0001188833,0.0001411946,0.0002579545,0.0001138161,0.0002522711,0.0003225435,0.0004406964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001518503,"about_ca_system_score_gemma":0.0001120885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001553491,"about_ca_topic_score_gemma":0.001135083,"domain_scores_codex":[0.9998899,0.0000155593,0.00000762644,0.00003177496,0.00001326105,0.00004192526],"domain_scores_gemma":[0.9997692,0.00006471419,0.00006723502,0.00002001211,0.00003127062,0.00004772823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00108971,0.0001100344,0.5703368,0.00006273141,0.0000649955,0.0002165479,0.0005688936,0.0001204936,0.4198196,0.0001445629,0.0001221098,0.0073435],"study_design_scores_gemma":[0.00001385353,0.0002494562,0.9925467,0.000010032,0.00002001483,0.0005505698,0.0003126108,0.0002771023,0.00576944,0.00005438566,0.0001927192,0.000003131852],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999665,0.00007539579,0.00004957136,0.000003150802,4.960488e-7,0.000001695136,0.00003349758,0.000001411728,0.0001697985],"genre_scores_gemma":[0.9997131,0.00003927242,0.0000555342,0.00001152595,0.000001294818,0.000002053695,0.00007932491,0.000002279524,0.00009548393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002599105,"threshold_uncertainty_score":0.008694947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955715066324408,"score_gpt":0.2530745438190283,"score_spread":0.2335173931557842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}