{"id":"W2121517459","doi":"10.1210/mend.15.2.0598","title":"Human Angiotensin II Type 1 Receptor Isoforms Encoded by Messenger RNA Splice Variants Are Functionally Distinct","year":2001,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; U.S. Public Health Service; Université de Sherbrooke; Brigham Young University","keywords":"Biology; Gene isoform; splice; Messenger RNA; Alternative splicing; Molecular biology; Receptor; Angiotensin II; RNA splicing; RNA; Cell biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001129005,0.0003407984,0.0003190107,0.00008186309,0.0003258207,0.00002376422,0.0003223159,0.0002849093,0.00108374],"category_scores_gemma":[0.00007351681,0.0003279331,0.0001702823,0.0001870059,0.00009577817,0.000008747314,0.0002590932,0.0002248591,0.00009594599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003390174,"about_ca_system_score_gemma":0.00005257826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006071679,"about_ca_topic_score_gemma":0.00002983717,"domain_scores_codex":[0.9979205,0.0001096078,0.0003436394,0.0007215998,0.0002140535,0.0006906264],"domain_scores_gemma":[0.9989184,0.000008738976,0.0001732036,0.0005376123,0.0002111661,0.0001508638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009800601,0.0001243383,0.0002854384,0.000005700255,0.0001465845,0.00008885191,0.00002076851,0.00003644459,0.9800352,0.0005222079,0.01785067,0.0007858305],"study_design_scores_gemma":[0.0009083621,0.00072485,0.0007304784,0.00001443018,0.00004642221,0.0002048969,0.00007213485,0.00003482672,0.7950282,0.0002895127,0.2014527,0.0004931325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882326,0.001612961,0.006668181,0.000579787,0.0006195127,0.000229649,0.00003282475,0.00006242534,0.001962104],"genre_scores_gemma":[0.9926291,0.0002081883,0.001128141,0.0009541867,0.0002958067,0.00003004366,0.0005425238,0.00007064048,0.004141435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1850069,"threshold_uncertainty_score":0.9999173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01056332934119436,"score_gpt":0.2399289011268597,"score_spread":0.2293655717856654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}