{"id":"W2121517459","doi":"10.1210/mend.15.2.0598","title":"Human Angiotensin II Type 1 Receptor Isoforms Encoded by Messenger RNA Splice Variants Are Functionally Distinct","year":2001,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; U.S. Public Health Service; Université de Sherbrooke; Brigham Young University","keywords":"Biology; Gene isoform; splice; Messenger RNA; Alternative splicing; Molecular biology; Receptor; Angiotensin II; RNA splicing; RNA; Cell biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001288101,0.0002193527,0.000200273,0.0001885976,0.00008375193,0.0003656601,0.0001290541,0.0001991284,0.001008837],"category_scores_gemma":[0.0002835728,0.000116122,0.0001845807,0.0001407043,0.0001735822,0.0001717472,0.0001035851,0.0002673982,0.0006404186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001135444,"about_ca_system_score_gemma":0.00009275451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000231574,"about_ca_topic_score_gemma":0.0003336736,"domain_scores_codex":[0.9998596,0.00002283493,0.00001322064,0.00003985872,0.0000341381,0.00003039214],"domain_scores_gemma":[0.9998426,0.00004663297,0.00004547727,0.00001812145,0.0000224561,0.00002467716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002434554,0.00001972433,0.001756332,0.00003657722,0.00001389638,0.0002830314,0.00003469158,0.00003474455,0.9889821,0.0003290497,0.00008153333,0.008184839],"study_design_scores_gemma":[0.0001257385,0.001751478,0.1322915,0.00003514429,0.0001762865,0.01597808,0.0002891179,0.001470411,0.8260286,0.00158532,0.02021941,0.00004886818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843712,0.006836171,0.006176917,0.0002017896,0.00006974633,0.00002413297,0.0005407596,0.00009103805,0.001688127],"genre_scores_gemma":[0.9904256,0.003223652,0.003666345,0.0001130877,0.00005373579,0.00002175526,0.001084984,0.00001468619,0.001396108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001008837,"threshold_uncertainty_score":0.003374875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01056332934119436,"score_gpt":0.2399289011268597,"score_spread":0.2293655717856654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}