{"id":"W2121518207","doi":"10.1371/journal.pone.0043840","title":"Age-Associated Hyper-Methylated Regions in the Human Brain Overlap with Bivalent Chromatin Domains","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Medical Research Council; Universitetet i Oslo; Multiple Sclerosis Society of Canada; Vertex Pharmaceuticals; Multiple Sclerosis Society; Wellcome Trust; Fondazione Italiana Sclerosi Multipla; Biogen; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Bivalent (engine); Epigenetics; DNA methylation; Biology; Chromatin; Methylation; Human brain; Differentially methylated regions; Gene; Genetics; Gene expression; Neuroscience; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499914,0.000149748,0.0002525108,0.0005950638,0.0001334517,0.0001846173,0.0001406027,0.0001480573,0.002092014],"category_scores_gemma":[0.000343081,0.0001349158,0.000172181,0.000365769,0.0001940797,0.0001355994,0.0003684656,0.0001931583,0.000308428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001033484,"about_ca_system_score_gemma":0.0001047603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008278918,"about_ca_topic_score_gemma":0.001571598,"domain_scores_codex":[0.9998645,0.00001376475,0.000009485733,0.00006349441,0.00002560025,0.00002307062],"domain_scores_gemma":[0.999644,0.00007641698,0.000148567,0.00003214755,0.00004250938,0.00005627273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006615042,0.00002724322,0.1220545,0.0001408812,0.0001481575,0.0003108417,0.000275918,0.0001492271,0.8618946,0.0002631357,0.0001628311,0.01391121],"study_design_scores_gemma":[0.000006744388,0.0001371168,0.969672,0.000007439962,0.00005405731,0.001353358,0.0001035444,0.0002784093,0.02693619,0.0003185538,0.001124545,0.000008173163],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955623,0.001737747,0.00159702,0.00002423659,0.000003663476,0.000005507869,0.0004191489,0.00002088882,0.0006294349],"genre_scores_gemma":[0.9966326,0.0005032059,0.001232407,0.00003496834,0.000008624037,0.00001027747,0.0007992366,0.000008014717,0.0007705533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002092014,"threshold_uncertainty_score":0.006998479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03969107178074408,"score_gpt":0.2593319140297841,"score_spread":0.21964084224904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}