{"id":"W2121522472","doi":"10.1038/bjp.2008.316","title":"Lack of effects of acemetacin on signalling pathways for leukocyte adherence may explain its gastrointestinal safety","year":2008,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Consejo Nacional de Ciencia y Tecnología; Canada Research Chairs","keywords":"Tolerability; Leukotriene B4; Pharmacology; Indometacin; Toxicity; Nitric oxide; Medicine; Leukotriene; Chemistry; Inflammation; Internal medicine; Enzyme inhibitor; Biochemistry; Adverse effect; Enzyme; Prostaglandin-Endoperoxide Synthase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004472355,0.0003475215,0.0004767753,0.0001556219,0.0001682122,0.000436686,0.0003088367,0.0005045721,0.003659287],"category_scores_gemma":[0.0005531458,0.0001173429,0.0004320269,0.0001415355,0.0004290058,0.0004139549,0.0002131016,0.0007621671,0.0005085408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004005902,"about_ca_system_score_gemma":0.0002805055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003571197,"about_ca_topic_score_gemma":0.0005430246,"domain_scores_codex":[0.9996279,0.0001179757,0.00004029796,0.00005232171,0.00009769428,0.00006369127],"domain_scores_gemma":[0.9994536,0.0001439011,0.0001789091,0.00007235643,0.00008976309,0.00006148053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002662018,0.0001246693,0.002914344,0.000400163,0.00004044127,0.0002515002,0.0000262904,0.0001038995,0.9848421,0.0001769596,0.00007015034,0.008387566],"study_design_scores_gemma":[0.0001560069,0.007425485,0.04920689,0.00007217407,0.0001343263,0.00251444,0.0001519456,0.001103121,0.9328554,0.0002881505,0.006081183,0.00001087728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813167,0.01263324,0.00346902,0.0004927931,0.00005719625,0.00007003448,0.0002611364,0.00005442024,0.001645445],"genre_scores_gemma":[0.9954456,0.001905953,0.001251605,0.0001299502,0.00002447297,0.00004263983,0.0001696541,0.00000696703,0.001023174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003659287,"threshold_uncertainty_score":0.01224148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05692321866976382,"score_gpt":0.3214333893584327,"score_spread":0.2645101706886689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}