{"id":"W2121527056","doi":"10.4049/jimmunol.1400111","title":"Structural and Functional Correlates of Enhanced Antiviral Immunity Generated by Heteroclitic CD8 T Cell Epitopes","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Epitope; Avidity; T cell; Major histocompatibility complex; MHC class I; Antigen; Biology; CD8; Cytotoxic T cell; Antibody; Epitope mapping; Immune system; Chemistry; Cell biology; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001003293,0.0001533154,0.00007373119,0.0001764528,0.00007899192,0.0001552259,0.0001077848,0.0003081814,0.0009557373],"category_scores_gemma":[0.00009325828,0.00008513728,0.0001058628,0.00006805936,0.0001881302,0.0001278812,0.00009850708,0.0003919431,0.0001609905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001632261,"about_ca_system_score_gemma":0.00005393594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001656236,"about_ca_topic_score_gemma":0.0001898072,"domain_scores_codex":[0.999917,0.00001264494,0.000007144668,0.00001909008,0.00001720049,0.00002693127],"domain_scores_gemma":[0.9998851,0.00002142422,0.00003285543,0.00001597698,0.00001152888,0.00003309961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006307427,0.00001805312,0.0005311619,0.000004769705,0.000001261725,0.00001668709,0.000004833496,0.00003441801,0.9990614,0.00003211849,0.000004908489,0.0002271667],"study_design_scores_gemma":[0.00002623706,0.0007872354,0.0844957,0.000003108855,0.0000118856,0.0007370429,0.00004803621,0.001983197,0.9113361,0.0001113767,0.0004558748,0.0000041718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991386,0.00008285914,0.000319723,0.00001174917,0.00000179788,0.000004319491,0.00006712556,0.000007653923,0.0003661689],"genre_scores_gemma":[0.9993767,0.00002917953,0.000249987,0.00001030942,0.000002268447,0.000006102384,0.0001204171,0.000002764284,0.0002023395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009557373,"threshold_uncertainty_score":0.003197253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007598309454567508,"score_gpt":0.209320544110256,"score_spread":0.2017222346556884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}