{"id":"W2121532472","doi":"10.2337/db10-0818","title":"Diminished Superoxide Generation Is Associated With Respiratory Chain Dysfunction and Changes in the Mitochondrial Proteome of Sensory Neurons From Diabetic Rats","year":2010,"lang":"en","type":"article","venue":"Diabetes","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Manitoba Health Research Council","keywords":"Mitochondrion; Oxidative stress; Biology; Oxidative phosphorylation; Internal medicine; Cytochrome c oxidase; Endocrinology; Mitochondrial respiratory chain; Citrate synthase; Respiratory chain; Superoxide; Reactive oxygen species; Biochemistry; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002074172,0.0001341463,0.000243909,0.00008290786,0.00006315589,0.00001757646,0.00004273463,0.000109854,0.0000276412],"category_scores_gemma":[0.0002341208,0.00008628854,0.00002534173,0.0001201918,0.00008042418,0.00005343546,0.00001232673,0.0001866123,0.000001753578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001468314,"about_ca_system_score_gemma":0.00002942872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003463992,"about_ca_topic_score_gemma":0.0003283428,"domain_scores_codex":[0.9990796,0.0001523783,0.0001468473,0.0002309771,0.0002120561,0.000178105],"domain_scores_gemma":[0.9994197,0.0001749482,0.00008331257,0.0002220794,0.00005195736,0.00004795847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002875476,0.00015475,0.09881806,0.00001109598,0.00005216432,0.000007651078,0.0009148911,4.511537e-7,0.8991782,0.000009251208,0.00004709879,0.0007776051],"study_design_scores_gemma":[0.002083559,0.000845423,0.2327079,0.00006716439,0.0001346761,4.614921e-7,0.0001777033,0.0004820394,0.7632194,0.0001230263,0.00005800258,0.0001005666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982421,0.00008313311,0.00000599022,0.0006980097,0.0001713999,0.0007113033,0.00004468606,0.00001968217,0.00002368267],"genre_scores_gemma":[0.9984413,0.000004637739,0.0002501587,0.0008258122,0.0001960579,0.0001554356,0.00007251767,0.00001768716,0.00003638796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1359588,"threshold_uncertainty_score":0.3518744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02117014824290486,"score_gpt":0.2311669534095755,"score_spread":0.2099968051666706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}